PMID: 3746680Apr 1, 1986Paper

Blocking effects of cobalt and related ions on the gamma-aminobutyric acid-induced current in turtle retinal cones

The Journal of Physiology
A Kaneko, M Tachibana

Abstract

Red-sensitive cone photoreceptors were isolated from the turtle retina, and GABA-induced currents were recorded under voltage clamp. The effect of Co2+, widely used as a blocker of chemical synapses, on the GABA-induced current was studied. Co2+ blocked the GABA-induced current evoked by local application either at the synaptic region (cone pedicle) or at the extra-synaptic region (cell body). 5 microM-Co2+ suppressed the GABA-induced current by 50%, and a few hundred microM-Co2+ blocked it almost completely. Co2+ suppressed the GABA-induced current non-competitively: the saturating response amplitude decreased without a change in the threshold or saturating dose of GABA. The blocking was not voltage dependent in the physiological range of the membrane potential. Ni2+ and Cd2+ also blocked the GABA-induced current non-competitively, and were as effective as Co2+. Tetraethylammonium (25 mM) showed a similar but weaker blocking effect. On the other hand, Mg2+ (20 mM), Mn2+, Sr2+, Ba2+ (10-100 microM each), D-600 (10 microM) or Cs+ (10 mM) did not affect the GABA-induced current. The Ca current in the turtle cones was blocked almost completely by 20 mM-Mg2+ or 4 mM-Co2+, or strongly suppressed by 10 microM-D-600. However, Cd2+ and...Continue Reading

Citations

Jun 1, 1997·Progress in Neurobiology·E Kumamoto
Dec 1, 1994·Cellular and Molecular Neurobiology·T NarahashiM Nakahiro
Oct 1, 1996·Molecular Neurobiology·T A Cleland
Mar 12, 2005·The Journal of Physiology·Tomomi Ichinose, Peter D Lukasiewicz
Jun 6, 1998·The Journal of Physiology·O Umino, T Ushio
Jan 5, 2005·Toxicology and Applied Pharmacology·Claudio CoddouJ Pablo Huidobro-Toro
May 15, 2012·Progress in Retinal and Eye Research·Wallace B Thoreson, Stuart C Mangel
Jul 1, 1995·Visual Neuroscience·T E Frumkes, R Nelson
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Jan 1, 1997·Microscopy Research and Technique·J Nguyen-LegrosC Savy
Apr 8, 1988·The Journal of Comparative Neurology·M E Pierce, J C Besharse
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Dec 1, 1990·British Journal of Pharmacology·H el-Beheiry, E Puil

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