Blocking FSH action attenuates osteoclastogenesis.

Biochemical and Biophysical Research Communications
Ling-Ling ZhuHarry C Blair

Abstract

A direct effect of FSH on bone turnover via stimulation of osteoclast formation has been reported. Here we show that monoclonal or polyclonal antibodies to FSH inhibit osteoclast formation induced by FSH to an extent similar to that noted in FSH receptor (FSHR) knockout cells. Furthermore, we document the amplification of FSHR cDNA from well-characterized human CD14+ osteoclast precursors and osteoclasts, and the direct sequencing of the PCR products to definitively establish the expression of FSHRs. At these sites, the FSHR was expressed predominantly as an isoform that omits exon 9, a linker between the FSH-binding region and a long, invariant signaling domain of the receptor. These data provide compelling evidence for expression of a FSH receptor isoform in osteoclasts and their precursors.

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Citations

Aug 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ling-Ling ZhuMone Zaidi
Aug 15, 2014·Annals of the New York Academy of Sciences·Irina L TourkovaHarry C Blair
Mar 30, 2013·Biochemical and Biophysical Research Communications·Wenxin GengFulin Chen
Oct 21, 2016·Journal of Bone Oncology·Caroline Wilson
Feb 15, 2018·Proceedings of the National Academy of Sciences of the United States of America·Yaoting JiMone Zaidi
Mar 21, 2018·American Journal of Physiology. Endocrinology and Metabolism·Sunmin ParkSuna Kang
Apr 24, 2018·Endocrine Reviews·Gherardo MazziottiAndrea Giustina
Mar 21, 2018·The Journal of Endocrinology·Mone ZaidiTony Yuen
Jun 14, 2018·Endocrine Reviews·Mone ZaidiClifford J Rosen
Nov 6, 2018·Endocrinology·Julie A W Stilley, Deborah L Segaloff
Aug 8, 2018·Endocrinology·Mone ZaidiTony Yuen
Feb 18, 2014·The Journal of Clinical Endocrinology and Metabolism·Julie A StilleyDeborah L Segaloff
Jun 11, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mone ZaidiTony Yuen
Aug 11, 2016·Hormone Molecular Biology and Clinical Investigation·Mone ZaidiTony Yuen
Mar 6, 2019·Frontiers in Endocrinology·Elodie KaraMarie-Christine Maurel
Apr 4, 2019·Frontiers in Endocrinology·Daria LiznevaMone Zaidi
Nov 1, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sakshi GeraMone Zaidi
Feb 13, 2021·International Journal of Environmental Research and Public Health·Young-Min ParkKerrie L Moreau
Dec 17, 2020·The Journal of Clinical Endocrinology and Metabolism·Annegreet G Veldhuis-VlugAnn V Schwartz
May 2, 2018·Molecular and Cellular Endocrinology·Julie A W Stilley, Deborah L Segaloff
May 25, 2021·International Journal of Immunopathology and Pharmacology·Lyudmila Belenska-TodorovaNina Ivanovska

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