Blocking HbS Polymerization in SCD

Cell
Guillaume Lettre

Abstract

Sickle cell disease (SCD) is caused by a point mutation in the β-globin gene that creates hemoglobin S (HbS). Upon deoxygenation, HbS forms long polymers that distort the shape of red blood cells, causing hemolysis and vaso-occlusion. Voxelotor inhibits HbS polymerization, the root cause of SCD complications. To view this Bench to Bedside, open or download the PDF.

References

Mar 25, 2017·ACS Medicinal Chemistry Letters·Brian MetcalfZhe Li
Apr 8, 2017·Blood·William A Eaton, H Franklin Bunn
Mar 16, 2018·Nature Reviews. Disease Primers·Gregory J KatoElliott P Vichinsky
Jun 15, 2019·The New England Journal of Medicine·Elliott VichinskyUNKNOWN HOPE Trial Investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Hiromitsu Kumada
Pediatric Clinics of North America
Emily Riehm Meier
Nihon rinsho. Japanese journal of clinical medicine
Fumitaka Suzuki, Hiromitsu Kumada
© 2021 Meta ULC. All rights reserved