Blocking IL-1 to prevent respiratory failure in COVID-19

Critical Care : the Official Journal of the Critical Care Forum
Frank L van de Veerdonk, Mihai G Netea

Abstract

COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it can progress into severe pneumonia and acute respiratory distress syndrome (ARDS). Inflammation is known to play a crucial role in the pathogenesis of severe infections and ARDS and evidence is emerging that the IL-1/IL-6 pathway is highly upregulated in patients with severe disease. These findings open new avenues for host-directed therapies in patients with symptomatic SARS-CoV-2 infection and might in addition to antiviral treatment be enough to curb the currently unacceptably high morbidity and mortality associated with COVID-19.

References

May 8, 2003·JAMA : the Journal of the American Medical Association·Christopher M BoothAllan S Detsky
Jun 5, 2003·Lancet·John M NichollsJ S Malik Peiris
Jul 17, 2003·JAMA : the Journal of the American Medical Association·Thomas W K LewSoon-Keng Goh
Jul 17, 2003·JAMA : the Journal of the American Medical Association·Gordon D Rubenfeld
Jan 1, 1959·The Journal of Clinical Investigation·D B LOURIAD E ROGERS
Mar 15, 2006·Lancet·Jan-Inge HenterYu-Lung Lau
May 13, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tracey BaasMichael G Katze
Jun 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeannette GuarnerSherif R Zaki
Oct 1, 2008·Nature Clinical Practice. Rheumatology·Alison Kelly, Athimalaipet V Ramanan
Nov 27, 2009·The New England Journal of Medicine·Peter F WrightJohn F Modlin
Dec 25, 2009·The New England Journal of Medicine·Yu-Wen ChienDavid M Morens
Feb 9, 2010·PLoS Pathogens·Saskia L SmitsBart L Haagmans
Apr 3, 2010·The Journal of Rheumatology·Madeleine DurandGenevieve Gregoire
Jun 17, 2010·American Journal of Clinical Pathology·Paul W HarmsJeffrey M Jentzen
Feb 3, 2011·Journal of Pediatric Hematology/oncology·Halil OzdemirUlker Doğru
Nov 19, 2013·The Lancet Infectious Diseases·Kirsty R ShortThijs Kuiken
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Antonella de LucaFrank L van de Veerdonk
Nov 12, 2014·Annual Review of Medicine·Grant S Schulert, Alexei A Grom
Apr 8, 2015·Clinical Rheumatology·Donato RiganteLuca Cantarini
Jan 28, 2016·Mucosal Immunology·K A ShireyS N Vogel
Mar 25, 2016·Nature Reviews. Rheumatology·Alexei A GromFabrizio De Benedetti
Feb 9, 2017·The New England Journal of Medicine·Yaseen M ArabiRobert A Fowler
Nov 22, 2018·Frontiers in Pharmacology·Giulio Cavalli, Charles A Dinarello
Dec 24, 2018·The New England Journal of Medicine·David M Morens, Jeffery K Taubenberger
Apr 16, 2020·Journal of Medical Virology·Jieyun ZhuChunling Zhao
Apr 24, 2020·Lancet·Zsuzsanna VargaHolger Moch
May 10, 2020·Intensive Care Medicine·Changsong WangKaijiang Yu
May 15, 2020·The Lancet. Haematology·Marcel LeviJerrold H Levy
May 15, 2020·The Journal of Allergy and Clinical Immunology·Ruchong ChenUNKNOWN Medical Treatment Expert Group for COVID-19
May 16, 2020·Cell Host & Microbe·George DimopoulosEvangelos J Giamarellos-Bourboulis
May 20, 2020·The Journal of Allergy and Clinical Immunology·Tobias HeroldTobias Weinberger
May 20, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Raef FadelUNKNOWN Henry Ford COVID-19 Management Task Force
May 21, 2020·Critical Care : the Official Journal of the Critical Care Forum·Xiaofan LuFangrong Yan
May 22, 2020·The New England Journal of Medicine·Maximilian AckermannDanny Jonigk
May 22, 2020·The Journal of Allergy and Clinical Immunology·Emanuele PontaliMarco Gattorno
May 23, 2020·Journal of Medical Virology·Wenjie TianRajeev Malhotra

❮ Previous
Next ❯

Citations

Sep 23, 2020·Open Biology·Antonella FaraBakri M Assas
Oct 8, 2020·Critical Care : the Official Journal of the Critical Care Forum·Rahul Gupta
Dec 1, 2020·Drug Development Research·Fatemeh BabaeiHossein Hosseinzadeh
Nov 21, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·A BalkhairO Balkhair
Nov 10, 2020·Frontiers in Pharmacology·Chih-Chao ChiangTsong-Long Hwang
Dec 5, 2020·Vaccines·Claudio CostantiniLuigina Romani
Feb 15, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Maryam Eskandari MehrabadiSaman Hosseinkhani
Jan 6, 2021·Archives of Pharmacal Research·Choongho Lee, Won Jun Choi
Mar 12, 2021·Expert Opinion on Pharmacotherapy·Juan Luis Gomez Marti, Adam M Brufsky
Mar 9, 2021·ELife·Evdoxia KyriazopoulouEvangelos J Giamarellos-Bourboulis
Apr 6, 2021·Computational and Structural Biotechnology Journal·Bhavnita Soni, Shailza Singh
Apr 13, 2021·Frontiers in Immunology·Nico ReuschAnna C Aschenbrenner
Apr 30, 2021·Frontiers in Immunology·Jintao ZhangWei Zhao
May 30, 2021·The Lancet. Respiratory Medicine·Frank L van de VeerdonkPaul E Verweij
Jun 1, 2021·Frontiers in Immunology·Xiaofang WangYuejin Liang
Jul 3, 2021·Infectious Disease Reports·Andrea FrustaciCristina Chimenti
Aug 11, 2021·Nature Reviews. Immunology·Setu M VoraHao Wu
Aug 28, 2021·International Journal of Molecular Sciences·Sirsendu JanaAbdu I Alayash

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.