Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19

The Journal of Experimental Medicine
Lars M KoenigSimon Rothenfusser

Abstract

An exacerbated and unbalanced immune response may account for the severity of COVID-19, the disease caused by the novel severe acute respiratory syndrome (SARS) coronavirus 2, SARS-CoV-2. In this Viewpoint, we summarize recent evidence for the role of neutrophils in the pathogenesis of COVID-19 and propose CXCR2 inhibition as a promising treatment option to block neutrophil recruitment and activation.

References

Jan 24, 2020·Nature Reviews. Drug Discovery·Tamás NémethAttila Mócsai
Apr 18, 2020·The Journal of Experimental Medicine·Betsy J BarnesMikala Egeblad
Apr 21, 2020·Journal of the American College of Cardiology·Behnood BikdeliUNKNOWN Global COVID-19 Thrombosis Collaborative Group, Endorsed by the ISTH, NATF, ESVM, and the IUA, Supported by the ESC Working
May 14, 2020·Nature Medicine·Mingfeng LiaoZheng Zhang
May 18, 2020·Cell·Daniel Blanco-MeloBenjamin R tenOever
Jun 9, 2020·Immunity·Nicolas VabretUNKNOWN Sinai Immunology Review Project
Jun 9, 2020·MedRxiv : the Preprint Server for Health Sciences·Yu ZuoJason S Knight

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Citations

Feb 9, 2021·Frontiers in Immunology·Rebeca Garcia-Fandino, Ángel Piñeiro
Mar 2, 2021·Frontiers in Immunology·Mohamed A ElTanboulyRandolph J Noelle
Mar 2, 2021·Frontiers in Immunology·Nicole PalandIgal Louria-Hayon
Apr 10, 2021·The FEBS Journal·Kaiwen LiuTian Hua
Jun 22, 2021·Frontiers in Immunology·Jon Hazeldine, Janet M Lord
Aug 24, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Apurwa SinghalSachin Kumar

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Methods Mentioned

BETA
bronchoalveolar lavage

Clinical Trials Mentioned

NCT04381936
NCT04343651
NCT04347239
NCT04441385
NCT04435522
NCT04347226

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