Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke.

Cells
Giuseppe SantopoloJonas Frisén

Abstract

Stroke triggers neurogenesis in the striatum in mice, with new neurons deriving in part from the nearby subventricular zone and in part from parenchymal astrocytes. The initiation of neurogenesis by astrocytes within the striatum is triggered by reduced Notch-signaling, and blocking this signaling pathway by deletion of the gene encoding the obligate Notch coactivator Rbpj is sufficient to activate neurogenesis by striatal astrocytes in the absence of an injury. Here we report that blocking Notch-signaling in stroke increases the neurogenic response to stroke 3.5-fold in mice. Deletion of Rbpj results in the recruitment of a larger number of parenchymal astrocytes to neurogenesis and over larger areas of the striatum. These data suggest inhibition of Notch-signaling as a potential translational strategy to promote neuronal regeneration after stroke.

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Citations

Jul 6, 2021·Frontiers in Cell and Developmental Biology·Tais Novaki RibeiroMarimelia A Porcionatto
Jun 18, 2021·Frontiers in Neuroscience·Ranran DuanYanjie Jia
Aug 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Matthijs C DorstChristian Göritz
Sep 2, 2021·EMBO Molecular Medicine·René G FeichtingerSaskia B Wortmann

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