Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Christiane Albert-WeissenbergerChristoph Kleinschnitz

Abstract

The two bradykinin receptors B1R and B2R are central components of the kallikrein-kinin system with different expression kinetics and binding characteristics. Activation of these receptors by kinins triggers inflammatory responses in the target organ and in most situations enhances tissue damage. We could recently show that blocking of B1R, but not B2R, protects from cortical cryolesion by reducing inflammation and edema formation. In the present study, we investigated the role of B1R and B2R in a closed head model of focal traumatic brain injury (TBI; weight drop). Increased expression of B1R in the injured hemispheres of wild-type mice was restricted to the later stages after brain trauma, i.e. day 7 (P<0.05), whereas no significant induction could be observed for the B2R (P>0.05). Mice lacking the B1R, but not the B2R, showed less functional deficits on day 3 (P<0.001) and day 7 (P<0.001) compared with controls. Pharmacological blocking of B1R in wild-type mice had similar effects. Reduced axonal injury and astroglia activation could be identified as underlying mechanisms, while inhibition of B1R had only little influence on the local inflammatory response in this model. Inhibition of B1R may become a novel strategy to count...Continue Reading

References

Oct 1, 1991·Journal of Neurochemistry·A J CholewinskiG P Wilkin
Jun 1, 1985·Journal of Neurochemistry·K KariyaT Sasaki
Jun 30, 1994·Nature·V ParpuraP G Haydon
May 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E ShohamiR Gallily
Jul 1, 1997·Journal of Neuroimmunology·D M Raidoo, K D Bhoola
Feb 16, 2000·Neuroreport·L ZhangD R Rubinow
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·J B PesqueroM Bader
Nov 1, 2001·Journal of Neurotrauma·N PlesnilaA Baethmann
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Oct 28, 2003·Journal of Neurotrauma·F HellalC Marchand-Verrecchia
Oct 2, 2004·Nature Reviews. Drug Discovery·François Marceau, Domenico Regoli
Apr 9, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Moritz GrögerNikolaus Plesnila
Apr 28, 2005·Current Pharmaceutical Design·D RodiM Simonato
Nov 29, 2005·Acta neurochirurgica·F TagliaferriJ Kraus
Dec 13, 2005·Brain : a Journal of Neurology·Anna-Leena SirénHannelore Ehrenreich
Dec 20, 2005·Acta neurochirurgica·A Büki, J T Povlishock
Nov 8, 2008·Stroke; a Journal of Cerebral Circulation·Madeleine AustinatChristoph Kleinschnitz
Aug 29, 2009·Nature Protocols·Michael A FlierlEsther Shohami
Sep 24, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Raimund TraboldNikolaus Plesnila
Jan 12, 2010·Neuropeptides·Mayra Tolentino Resk LemosHudson Sousa Buck
Mar 4, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Furat RaslanChristoph Kleinschnitz
Sep 30, 2010·PLoS Biology·Christoph KleinschnitzHarald H H W Schmidt
Feb 4, 2012·Experimental & Translational Stroke Medicine·Christiane Albert-WeißenbergerAnna-Leena Sirén
Feb 10, 2012·Journal of Neuropathology and Experimental Neurology·Tony FrugierYona Goldshmit

❮ Previous
Next ❯

Citations

Mar 1, 1988·Clinical Radiology·D M HadleyJ O Rowan
Jul 22, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·P C Blumbergs
Jan 7, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Michael Gaetz
Jan 7, 2014·Current Treatment Options in Neurology·Danielle K Sandsmark, Kevin N Sheth
Feb 5, 2014·Translational Stroke Research·Yi Ping ZhangChristopher B Shields
Mar 7, 2014·Human Molecular Genetics·You-hai XuGregory A Grabowski
Oct 26, 2012·Expert Opinion on Drug Discovery·Eric T WhalleyKanti D Bhoola
Jan 24, 2016·Journal of Neuropathology and Experimental Neurology·Hongxing WangXiao-Ming Xu
Jan 1, 2013·Progress in Neurobiology·Christiane Albert-WeißenbergerChristoph Kleinschnitz
Nov 28, 2015·Current Opinion in Pharmacology·Nikolaus Plesnila
Jul 23, 2015·Neural Regeneration Research·Sarah Hopp, Christiane Albert-Weissenberger
Aug 2, 2014·Journal of Neuroimmunology·Stine MenclChristoph Kleinschnitz
Nov 19, 2014·Frontiers in Cellular Neuroscience·Christiane Albert-WeissenbergerAnna-Leena Sirén
Sep 25, 2014·Frontiers in Cellular Neuroscience·Christiane Albert-WeissenbergerChristoph Kleinschnitz
Apr 5, 2016·Annals of Neurology·Sarah HoppChristoph Kleinschnitz
Apr 4, 2015·Cell Transplantation·Priscilla D NegraesHenning Ulrich
Nov 24, 2017·Expert Opinion on Therapeutic Targets·Fatimunnisa Qadri, Michael Bader
Aug 24, 2019·Journal of Neurotrauma·Liga ZvejnieceMaija Dambrova
Dec 17, 2015·Biological Chemistry·Káris E Dong-CresteHudson S Buck
Feb 22, 2017·Journal of Neuroinflammation·Sarah HoppChristiane Albert-Weissenberger
Feb 6, 2019·Frontiers in Neurology·Anelia A Y KassiShyam Gajavelli
Jan 22, 2019·Journal of Neurotrauma·Colleen N BodnarAdam D Bachstetter
Sep 25, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Chhinder P SodhiHongpeng Jia
Jun 3, 2021·International Journal of Molecular Sciences·Christian StetterChristiane Albert-Weißenberger

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
Assay

Software Mentioned

StatMate
GraphPad
PrismGraph

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Furat RaslanChristoph Kleinschnitz
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Raimund TraboldNikolaus Plesnila
© 2021 Meta ULC. All rights reserved