PMID: 9000038Jan 1, 1997Paper

Blocking of TNF-alpha and IL-1 inhibits leukocyte infiltration at early, but not at late stage of S. aureus-induced arthritis and the concomitant cartilage destruction in rabbits

Clinical Immunology and Immunopathology
M KimuraM Yoshinaga

Abstract

We investigated the involvement of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in the pathogenesis of heat-killed S. aureus-induced arthritis. TNF-alpha and IL-1beta peaked at 2 and 24 hr after the injection, respectively. Leukocyte infiltration within 12 hr of the inflammation was significantly inhibited (80%) by coinjection of anti-TNF-alpha mAb and IL-1 receptor antagonist (IL-1Ra) with S. aureus; however, leukocyte infiltration at 24 hr and thereafter was not inhibited by these agents. The loss of proteoglycan in S. aureus-induced arthritis was also unchanged either by anti-TNF-alpha mAb, IL-1Ra, or their combination. These results indicate that direct participation of TNF-alpha and IL-1 in the pathogenesis of S. aureus-induced arthritis may be limited to the early stage of inflammation and blocking of these cytokines did not result in diminishing the severity of inflammation. Thus, therapeutic approaches with the objective to suppress TNF-alpha and IL-1 may not be effective in the clinical treatment of gram-positive bacteria-induced arthritis.

Citations

Oct 14, 2006·Breast Cancer Research and Treatment·Lida MinaKathy D Miller
Jul 13, 2005·DNA and Cell Biology·Karen E YatesRichard G Reish
Jun 6, 2008·Current Opinion in Rheumatology·Dimitrios A Pappas, Jon T Giles
Jul 7, 2018·International Forum of Allergy & Rhinology·Xianmin WuMinghui Jia
Mar 30, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nicholas M BernthalLloyd S Miller
Sep 6, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Steven B CohenDavid R Diduch
Jan 5, 2011·International Journal of Rheumatic Diseases·Denglu YanFuxing Pei
Jan 25, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yu WangLloyd S Miller
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lloyd S MillerRobert L Modlin

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