Blocking the transient receptor potential vanilloid-1 does not reduce the exercise pressor reflex in healthy rats

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Guillaume P DucrocqMarc P Kaufman

Abstract

Controversy exists regarding the role played by transient receptor potential vanilloid-1 (TRPV1) in evoking the exercise pressor reflex. Here, we determine the role played by TRPV1 in evoking this reflex while assessing possible confounding factors arising from TRPV1 antagonists or from the vehicle in which they were dissolved. The exercise pressor reflex was evoked in decerebrated, anesthetized Sprague-Dawley rats by electrical stimulation of the tibial nerve to contract the triceps surae muscles statically. This procedure was repeated before and after injection of the TRPV1 blockers: capsazepine (100 μg/100 μL), ruthenium red (100 μg/100 μL), or iodoresiniferatoxin (IRTX; 1 μg/100 μL). We found that capsazepine decreased the exercise pressor reflex when the drug was dissolved in DMSO (-10 ± 9 mmHg; P = 0.015; n = 7). However, similar reduction was found when DMSO alone was injected (-8 ± 5 mmHg; P = 0.023; n = 5). Capsazepine, dissolved in ethanol (2 ± 6 mmHg; P = 0.49; n = 7), ruthenium red (-4 ± 12 mmHg; P = 0.41; n = 7), or IRTX (4 ± 18 mmHg; P = 0.56; n = 7), did not significantly decrease the exercise pressor reflex. In addition, we found that capsazepine and ruthenium red had "off-target" effects. Capsazepine decreased ...Continue Reading

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Citations

Jan 31, 2020·Exercise and Sport Sciences Reviews·André L TeixeiraLauro C Vianna
Nov 2, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Guillaume P DucrocqMarc P Kaufman
May 10, 2021·Exercise and Sport Sciences Reviews·Masaki MizunoScott A Smith
Jul 15, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph MannozziDonal S O'Leary

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