Blonanserin, an antipsychotic and dopamine D₂/D₃receptor antagonist, and ameliorated alcohol dependence

Clinical Neuropharmacology
Manabu Takaki, Hiroshi Ujike


Blonanserin (BNS) is used for treatment of both positive and negative symptoms of schizophrenia in Japan and Korea. Because BNS has weak α1 receptor blocking activities and is almost devoid of histamine H1 and muscarinic M1 antagonist activity, BNS is better tolerated than other atypical antipsychotics. A high degree of D₃ receptor blockage is reported to be predictive of drug abuse and alcoholism, and BNS has strong D₃ receptor antagonism. Thus, BNS may be useful in the treatment of alcoholism. We present a case in which BNS ameliorated alcohol dependence.


Jul 5, 2005·Drug Discovery Today·Jeffrey N Joyce, Mark J Millan
Nov 2, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Valentina VengelieneRainer Spanagel
Dec 25, 2009·CNS Drugs·Emma D Deeks, Gillian M Keating
Dec 1, 2012·Acta Neuropsychiatrica·Manabu TakakiYosuke Uchitomi

Related Concepts

Alcohol Abuse
Antipsychotic Effect
Dopamine D2 Receptor
Dopamine Antagonists
Dopamine D3 receptor
Dopamine D2 Receptor Antagonists

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