Blood 25-hydroxyvitamin D3 concentrations and incident sporadic colorectal adenoma risk: a pooled case-control study.

American Journal of Epidemiology
Veronika FedirkoMyron D Gross

Abstract

The authors examined the association between circulating 25-hydroxyvitamin D(3) (25(OH)D(3)), the best indicator of total vitamin D exposure, and incident, sporadic colorectal adenoma risk in a pooled analysis of primary data from 3 colonoscopy-based case-control studies conducted in Minnesota, North Carolina, and South Carolina between 1991 and 2002. The pooled study included 616 colorectal adenoma cases and 770 polyp-free controls. Multivariable logistic regression was used to estimate the association between circulating 25(OH)D(3) and colorectal adenoma risk. Stratified analyses and the likelihood ratio test were used to examine effect modification by various risk factors. In the pooled analysis, higher circulating 25(OH)D(3) concentrations were statistically significantly associated with decreased colorectal adenoma risk (highest vs. lowest quartile odds ratio = 0.59, 95% confidence interval: 0.41, 0.84). The observed inverse association was stronger among participants who used nonsteroidal antiinflammatory drugs regularly (highest vs. lowest quartile odds ratio = 0.33, 95% confidence interval: 0.19, 0.56). Inverse associations between 25(OH)D(3) and colorectal adenoma did not differ substantially by other risk factors or b...Continue Reading

References

Dec 1, 1990·Archives internationales de physiologie et de biochimie·P Pérez-RodrigoJ M López-Novoa
Jan 1, 1988·American Journal of Epidemiology·W C WillettF E Speizer
Sep 1, 1980·International Journal of Epidemiology·C F Garland, F C Garland
Sep 15, 1995·American Journal of Epidemiology·M M BraunG W Comstock
Jun 1, 2002·Archives of Internal Medicine·Jerome L Abramson, Viola Vaccarino
Jul 5, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·B D BoyanZ Schwartz
Apr 12, 2003·Obesity Research·Monica BullóJordi Salas-Salvadó
Aug 2, 2003·Nature Reviews. Cancer·Sergio A Lamprecht, Martin Lipkin
Dec 5, 2003·Journal of the National Cancer Institute·Maria V GrauDavid Heber
Apr 24, 2004·The Cochrane Database of Systematic Reviews·T K Asano, R S McLeod
Jan 27, 2005·The Journal of Nutrition·David A Hanley, K Shawn Davison
Aug 13, 2005·World Journal of Gastroenterology : WJG·You-Ling GongZhi-Hong Gong
Aug 25, 2005·JAMA : the Journal of the American Medical Association·Andrew T ChanCharles S Fuchs
Oct 11, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Damien MatusiakRichard V Benya
Oct 21, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Edward D GorhamMichael F Holick
Jan 13, 2006·Molecular and Cellular Endocrinology·Regina EbertFranz Jakob
Feb 17, 2006·The New England Journal of Medicine·Jean Wactawski-WendeUNKNOWN Women's Health Initiative Investigators
Oct 7, 2006·The American Journal of Clinical Nutrition·Lisa A Houghton, Reinhold Vieth
Jan 16, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Elizabeth T JacobsMaría Elena Martínez
Feb 3, 2007·International Journal of Cancer. Journal International Du Cancer·Tetsuya OtaniUNKNOWN Japan Public Health Center-based Prospective Study Group
Mar 24, 2007·American Journal of Epidemiology·Kyungwon OhEdward L Giovannucci
Jul 12, 2007·British Journal of Cancer·T OtaniUNKNOWN Japan Public Health Center-Based Prospective Study Group
Jul 12, 2007·Journal of the National Cancer Institute·Kana WuEdward L Giovannucci
Sep 19, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Damien Matusiak, Richard V Benya
Apr 11, 2008·The American Journal of Clinical Nutrition·Michael F Holick, Tai C Chen
Aug 12, 2008·The American Journal of Clinical Nutrition·Ann PrenticeInez Schoenmakers
Nov 8, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Melissa Y WeiEdward Giovannucci
Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Carrie R DanielMarch E Seabrook
May 9, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Eduard SidelnikovVeronika Fedirko
Jan 9, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christy G WoolcottLoïc Le Marchand

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Citations

Apr 11, 2012·Inflammatory Bowel Diseases·Caroline HwangUma Mahadevan
Aug 9, 2013·Journal of Gastrointestinal Cancer·Alexander M Sy, Josef Edrik Keith Bautista
Mar 25, 2011·Nutrition and Cancer·Scott V AdamsJohn D Potter
Jan 16, 2013·Endocrine-related Cancer·Carlien LeyssensAnnemieke Verstuyf
Oct 3, 2013·Nutrients·Andre Y O M CarvalhoLynnette R Ferguson
Aug 11, 2012·Endocrinology and Metabolism Clinics of North America·Heidi Wolden-KirkChantal Mathieu
Jun 2, 2012·Journal of Chiropractic Medicine·Ralph A Kruse, Jerrilyn A Cambron
Aug 4, 2015·Digestive Diseases and Sciences·Prashanthi N ThotaMadhusudhan R Sanaka
Jun 16, 2011·Preventive Medicine·Lu YinHermann Brenner
Jun 12, 2013·International Journal of Cancer. Journal International Du Cancer·Elizabeth T JacobsPeter W Jurutka
Aug 11, 2015·Molecular Carcinogenesis·Bharat ThyagarajanRoberd M Bostick
Apr 5, 2015·Digestive Diseases and Sciences·Myong Ki BaegSang-Woo Kim
Jan 20, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Roberd M Bostick
Jan 28, 2017·Nutrition and Cancer·Caroline Y UmRoberd M Bostick
Jan 20, 2017·Journal of Digestive Diseases·Jing-Yuan FangUNKNOWN Chinese Society of Gastroenterology and the Committee on Gastrointestinal Tumors of the Chinese Society of Gastroenterology
Mar 17, 2017·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Ronald C EldridgeMichael Goodman
Jan 13, 2018·Molecular Carcinogenesis·Bharat ThyagarajanRoberd M Bostick
Jul 28, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nicholas J KoszewskiJesse P Goff
Aug 14, 2015·World Journal of Gastroenterology : WJG·Yoon Ji ChoiJung Eun Lee
Mar 31, 2015·Cancer Prevention Research·Paulette D ChandlerJennifer H Lin
Apr 28, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Thomas U AhearnRoberd M Bostick
Aug 29, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Doratha A ByrdRoberd M Bostick
Feb 9, 2021·JBMR Plus·John D SluyterRobert Scragg

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