PMID: 2863043Jan 1, 1985

Blood acid-base status, whole blood and whole body buffer values in sand rats (Psammomys obesus) exposed to hypercapnia

Comparative Biochemistry and Physiology. A, Comparative Physiology
A Bar-IlanS Samueloff

Abstract

Arterial blood acid-base status of unanesthetized sand rats (Psammomys obesus) were studied under normocapnic and hypercapnic conditions, and compared to those obtained for the albino rat (Rattus norvegicus). The average control blood pH: 7.396 +/- 0.034; PaCO2: 30.5 +/- 2.9 mmHg; HCO-3: 18.8 +/- 2.5 mM/l; and HCO-3 std: 20.9 +/- 2.1 (N = 15) obtained here for the sand rat are in the lower range of values found in other mammals and indicate a status of partially compensated metabolic acidosis. The blood buffer values of the sand rat, delta log PCO2/delta pH = -2.32 +/- 0.35 (N = 25) are significantly higher than those found here for the rat, delta log PCO2/delta pH = -1.51 +/- 0.10 (N = 39), and those reported for other mammals. This high blood buffer value may be related to the natural high mineral diet of the sand rat. The in vivo (whole body) buffer value delta log PaCO2/delta pH = -1.41 and -1.65 for the sand rat and the rat found here are higher than those reported for the man and dog and may represent a physiological adaptation to the hypercapnic conditions prevailing in underground burrows.

References

Oct 11, 1992·Respiration Physiology·B R Williams, D L Kilgore
Apr 1, 1993·Journal of Basic and Clinical Physiology and Pharmacology·B Pinshow

Citations

Mar 7, 1978·Journal of Theoretical Biology·K J Wilson, D L Kilgore
Mar 1, 1972·Life Sciences. Pt. 1: Physiology and Pharmacology·G Frenkel, P F Kraicer
Jul 1, 1973·European Journal of Clinical Investigation·P LeuenbergerD R Held
Jan 1, 1968·Respiration Physiology·J C MithoeferW F Porter
Jan 1, 1984·Comparative Biochemistry and Physiology. A, Comparative Physiology·A Bar-IlanS Samueloff
Mar 1, 1980·Pflügers Archiv : European journal of physiology·A Bar-Ilan, J Marder
Apr 1, 1982·Respiration Physiology·M Brun-PascaudJ J Pocidalo
Feb 14, 1964·Science·K SCHMIDT-NIELSEND B HACKEL
May 1, 1964·The Journal of Clinical Investigation·J J COHENW B SCHWARTZ

Related Concepts

Whole Blood
August Rats
Rats, Sand
Ondatra
Whole Body
Compensated Metabolic Acidosis
Ampholytes
Gases, Blood, pH Only
Hypercapnia
Psammomys obesus

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