Blood adiponectin levels are not associated with risk of cardiovascular events in patients with type 2 diabetes

Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease
Ja Young JeonDae Jung Kim

Abstract

We examined whether circulating adiponectin levels are associated with further cardiovascular events in patients with type 2 diabetes. Between December 2004 and February 2005, 349 patients with type 2 diabetes were enrolled and followed-up until December 2015. Blood levels of total, middle-molecular weight and high-molecular weight adiponectin were measured at baseline. The primary composite outcome was the occurrence of the following events: cardiovascular death, non-fatal myocardial infarction, non-fatal stroke or hospitalization for unstable angina and heart failure. During a median follow-up of 9 years, cardiovascular events occurred in 14% of patients (50/349, 1.9% per year). Median blood levels of total, middle-molecular weight and high-molecular weight adiponectin were 4.8, 3.2 and 1.8 μg/mL, respectively. The cumulative incidence of cardiovascular events was not significantly different between the three groups based on total, middle-molecular weight, high-molecular weight or high-molecular weight/total adiponectin. After adjustment for potential confounding factors, blood adiponectin levels were positively associated with an increased number of cardiovascular events, but between tertiles, there was no significant differ...Continue Reading

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Citations

Aug 16, 2019·Cardiovascular Diabetology·Zengliang WangShuo Wang

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
coronary artery bypass

Software Mentioned

SPSS
SAS

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