PMID: 9179968Jul 1, 1995Paper

Blood amounts and suppressive in vitro activity of CD8+11b(+)-lymphocytes from HIV-infected children, related to hepatitis B or C virus association

Romanian Journal of Virology
C VoiculescuA Turculeanu

Abstract

In HIV only, as well as in HIV/hepatitis B- and HIV/hepatitis C-infected children (6 to 8 years of age), with moderate altered clinical and immune cell markers, the total amounts of CD8(+)-set and of CD8+11b(+)-subset (T-suppressor) blood lymphocytes, by means of flow cytometry, were determined. On the other hand, within several mixtures of autologous sorted CD3+/CD8+11b(+)-cells, the per cent reduction of HLA-DR+ expression on T-cells, at different effector/responder cell ratios, was appreciated. Significant higher levels of CD8+11b(+)-cells, especially in HIV/hepatitis B virus groups, were found, that correlated with a stronger suppressive activity. The strongest alteration of immune markers, within HIV-seropositive, HBs+, HBe+ patients, was noticed. A possible usefulness of these data in HIV only, and in HIV-associated hepatitis B or C virus contamination, during pediatric AIDS monitoring, was commented.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.