Abstract
The exact cause of breast cancer is unknown; it is a multifactorial disease. It is the most diagnosed and the second killer cancer among women. Breast cancer can be originated from tissues of breast or secondary from other organs via metastasis. Generally, cancer cells show aberrant metabolism and oxidative stress when compared to noncancerous tissues of breast cancer patients. The current study aims at evaluating glutamate and glucose metabolism through GDH and LDH enzyme activities, oxidant, and antioxidative status among breast cancer patients attending referral hospitals of Addis Ababa, Ethiopia. Result. Catalytic activities of glutamate dehydrogenase, lactate dehydrogenase, and oxidative stress index were significantly increased in both serum (4.2 mU/ml, 78.6 mU/ml, and 3.3 : 1, resp.) and cancerous tissues (1.4 mU/ml, 111.7 mU/ml, and 2.15 : 1, resp.) of breast cancer patients as compared to those in serum of control group (3.15 mU/ml, 30.4 mU/ml, and 2.05 : 1, resp.) and noncancerous tissues of breast cancer patients (0.92 mU/ml, 70.5 mU/ml, and 1.1 : 1, resp.) (P ≤ 0.05). Correspondingly, ratios of reduced to oxidized glutathione were significantly decreased in both serum (20 : 1) and cancerous tissues (23.5 : 1) of bre...Continue Reading
References
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Jan 16, 1995·FEBS Letters·S ToyokuniH Hiai
Aug 1, 1993·Cancer·R R PerryS C Barranco
Aug 19, 2000·Diseases of the Colon and Rectum·S C BarrancoP Kolm
May 1, 2001·Journal of Clinical Pathology·D KoracevicV Cosic
Oct 13, 2001·Breast Cancer Research : BCR·N S Brown, R Bicknell
Oct 11, 2005·Clinical Biochemistry·Ozcan Erel
Jan 21, 2006·Cancer Research·Michael I KoukourakisEfthimios Sivridis
Feb 1, 2006·Cell Biochemistry and Function·Derya Erten SenerMeral Torun
May 26, 2006·Nature·Jacques PouysségurNathalie M Mazure
Jan 27, 2007·Blood·Karin FischerMarina Kreutz
Apr 5, 2007·Nature Protocols·Irfan RahmanSaibal K Biswas
Apr 7, 2007·Cancer Metastasis Reviews·Pawel SwietachAdrian L Harris
Jun 10, 2008·Cancer Cell·Guido Kroemer, Jacques Pouyssegur
Oct 29, 2008·Mutation Research·Jorge Limón-Pacheco, María E Gonsebatt
Dec 18, 2008·Gynecologic and Obstetric Investigation·Michael I KoukourakisVassilios Liberis
Aug 5, 2010·Journal of Cellular Physiology·Ellen FridayFrancesco Turturro
Sep 14, 2010·Cancer Cell·Weiqin LuPeng Huang
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Apr 22, 2011·Nature Reviews. Cancer·Willem H KoppenolChi V Dang
Oct 5, 2011·International Journal of Clinical Oncology·Jia-Fu FengDong Wang
Oct 18, 2011·Endocrine-related Cancer·Dong WangYu-Wei Yang
Aug 21, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Michael P GamcsikO Michael Colvin
Oct 17, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Donald M MillerKara Sedoris
Jul 23, 2013·Advances in Cancer Research·Agnieszka Jezierska-DrutelCarola A Neumann
Nov 30, 2013·Nature Reviews. Drug Discovery·Chiara GorriniTak W Mak
Jan 1, 2013·Contemporary Oncology Współczesna Onkologia·Miłosława Maria Zowczak-DrabarczykMaria Litwiniuk
Aug 16, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Dennis BotmanCornelis J F Van Noorden
Jun 1, 2012·Balkan Medical Journal·Ahmet Fikret YücelIshak Sefa Tüzün
Feb 12, 2015·Cancer Cell·Lingtao JinSumin Kang
Feb 24, 2015·Cancer Cell International·Abdolhassan TalaiezadehSiavash Mansouri
May 8, 2015·Journal of Translational Medicine·Gaojie LiuBing Zeng
Nov 18, 2015·Oxidative Medicine and Cellular Longevity·Antonio Luiz Gomes JúniorAna Amélia de Carvalho Melo Cavalcante
Dec 24, 2015·Oxidative Medicine and Cellular Longevity·C PanisR Cecchini
Jan 26, 2016·Oncogenesis·K L EalesD A Tennant
May 3, 2016·Journal of Clinical and Diagnostic Research : JCDR·Aditi AgrawalM V R Reddy
Aug 6, 2016·Nature Reviews. Cancer·Brian J AltmanChi V Dang
Jan 20, 2017·PloS One·Rong WuXiao-Bo Du