Blood and urinary concentrations of salbutamol in asthmatic subjects

Medicine and Science in Sports and Exercise
Jimmi ElersVibeke Backer

Abstract

Data on blood and urinary concentrations of salbutamol after inhalation and oral administration in healthy subjects are scarce. Accordingly, we examined the pharmacokinetics of inhaled and oral salbutamol in asthmatic subjects. We enrolled 10 men aged 18-45 yr in an open-label study in which 0.8 mg of inhaled or 8 mg of systemic salbutamol was administered in a crossover design. All subjects had doctor-diagnosed asthma, used beta2 agonist when needed, and abstained from any medicine, beta2 agonist inclusive, for 14 d before visit. Urine was collected from all subjects (0-4, 4-8, and 8-12 h), and blood samples were taken at 0, 0.5, 1, 2, 3, 4, and 6 h after salbutamol administration. Maximum urine concentration was reached during the first 4 h after administration of both inhaled and oral salbutamol. We found differences in median urinary concentrations (Cmax) of 260.9 and 2422.2 ng x mL(-1), respectively (P < 0.005). Urinary concentrations show high individual variability irrespective of the route of administration. Blood analyses showed a systemic exposure of salbutamol after both inhaled and oral salbutamol with peak concentration after inhalation before the oral intake (P < 0.05). A difference in median Cmax after inhalation...Continue Reading

References

May 26, 1998·The Journal of Allergy and Clinical Immunology·I J HeleniusT Haahtela
Jul 2, 1998·Journal of Pharmaceutical Sciences·P J AndersonF C Hiller
Nov 26, 1999·The European Respiratory Journal·E F JuniperD R King
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J B LangdeauL P Boulet
Jun 12, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Simon F ThomsenVibeke Backer
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Mar 17, 2006·International Journal of Sports Medicine·A PichonA Denjean
Nov 7, 2006·Clinical Reviews in Allergy & Immunology·Sandra D AndersonJohn D Brannan
Dec 20, 2007·Medicine and Science in Sports and Exercise·Benjamin C SporerDonald C McKenzie
Jan 2, 2008·The European Respiratory Journal·E D BatemanH J Zar
Mar 5, 2008·Allergy·K-H Carlsen, M L Kowalski
May 13, 2008·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Benjamin C SporerDonald C McKenzie

❮ Previous
Next ❯

Citations

Jun 28, 2011·Expert Review of Respiratory Medicine·Jimmi ElersVibeke Backer
Aug 1, 2014·Scandinavian Journal of Medicine & Science in Sports·M HostrupV Backer
Dec 26, 2015·Respiratory Research·Fabien PillardDaniel Rivière
Nov 19, 2010·Scandinavian Journal of Medicine & Science in Sports·J ElersV Backer
Jul 10, 2013·Scandinavian Journal of Medicine & Science in Sports·A KalsenV Backer
Feb 8, 2018·Respiratory Research·Omar S UsmaniToby M Maher
Dec 7, 2017·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Rebecca L CordellPaul S Monks
Mar 6, 2012·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Jimmi ElersVibeke Backer
Jan 22, 2020·Drug Testing and Analysis·Morten HostrupAnders Krogh Lemminger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.