Blood-based biomarkers for diagnosis, prognosis and treatment of colorectal cancer

Clinica Chimica Acta; International Journal of Clinical Chemistry
Ebru E YörükerUgur Gezer

Abstract

The global burden of colorectal cancer (CRC)-associated morbidity and mortality is increasing, in part due to a lack of early detection. Direct structural examination techniques, such as colonoscopy, are invasive and can therefore affect the willingness of patients to participate in screening. Recently, the use of "liquid biopsy" has gained considerable attention as a novel source of biomarkers. Blood-based biomarkers could prove to be practical tools for CRC detection, as the monitoring of biomarkers in biological fluids offers many advantages, including minimal invasiveness and easy accessibility. Biomarkers with high specificity and sensitivity can enable the detection of CRC at an early stage, thereby improving prognosis, prediction of treatment response, and recurrence risk. In this review, we summarize that the biomarkers currently thought to have potential for the early detection and monitoring of CRC, including circulating tumor cells, DNA, RNA and proteins.

References

Jul 19, 2002·International Journal of Cancer. Journal International Du Cancer·Thierry LecomtePierre Laurent-Puig
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem
Nov 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Frank DiehlBert Vogelstein
Nov 17, 2006·Annals of the New York Academy of Sciences·Milo FrattiniMarco A Pierotti
Nov 17, 2006·Annals of the New York Academy of Sciences·Bret TabackDave S B Hoon
Dec 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emanuela FlaminiDino Amadori
Dec 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maike WallnerFrank T Kolligs
Jan 18, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George P KimUNKNOWN National Cancer Institute
Oct 13, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sabrina HundtHermann Brenner
Nov 21, 2007·Surgical Oncology·L BoniR Dionigi
Mar 5, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rafael G AmadoDavid D Chang
Mar 14, 2008·The New England Journal of Medicine·Fortunato Ciardiello, Giampaolo Tortora
May 20, 2008·Clinical Chemistry·Ugur DeligezerNejat Dalay
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Aug 2, 2008·Nature Medicine·Frank DiehlLuis A Diaz
Oct 8, 2008·Annals of the New York Academy of Sciences·Heidi SchwarzenbachEray Goekkurt
Oct 24, 2008·The New England Journal of Medicine·Christos S KarapetisJohn R Zalcberg
Dec 25, 2008·Critical Reviews in Clinical Laboratory Sciences·Stefan Holdenrieder, Petra Stieber
Mar 14, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S J CohenN J Meropol
Sep 15, 2009·Clinical Biochemistry·Maniesh van der Vaart, Pieter J Pretorius
Sep 19, 2009·Nature Reviews. Genetics·Carlo M Croce
Oct 31, 2009·International Journal of Cancer. Journal International Du Cancer·Zhaohui HuangXiang Du
Dec 17, 2009·Annals of Surgery·Benoit LefebureThierry Frebourg
Apr 28, 2010·Gastroenterology·Maria S Pino, Daniel C Chung
May 25, 2010·Epigenomics·Melanie Ehrlich
Sep 18, 2010·Clinical Chemistry·Jessica A WeberKai Wang
Nov 3, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K F NewtonJ Hill
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Max S Wicha, Daniel F Hayes
Jun 8, 2011·Nature Reviews. Clinical Oncology·Maria Angelica CortezGeorge A Calin
Jun 15, 2011·Molecular Cancer Research : MCR·Andrew J ArmstrongMariano A Garcia-Blanco
Sep 13, 2011·PloS One·Florent MouliereAlain R Thierry
Oct 25, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David A AhlquistGraham P Lidgard
Dec 16, 2011·BMC Medicine·Jorja D WarrenKaren A Heichman
Feb 7, 2012·Journal of Cellular and Molecular Medicine·Jorge BarbazánRafael López-López

❮ Previous
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Citations

Jul 22, 2016·Human Molecular Genetics·Devon M CayerNicholas J Schork
Oct 16, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y F SongQ Lin
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ahmed ElshafeiTarek Salman
Nov 18, 2017·Gastroenterology Research and Practice·Nina Hauptman, Damjan Glavač
Aug 9, 2018·Scientific Reports·Xianjin ZhuYanfang Song
Jun 8, 2017·Oncology Letters·Niki ChristouMuriel Mathonnet
May 19, 2020·Archives of Physiology and Biochemistry·Olfat G ShakerAmr M Abdelhamid
Aug 4, 2019·Scientific Reports·Akram MohammedRishikesan Kamaleswaran
Jun 15, 2019·International Journal of Molecular Sciences·Amanda C DaulagalaAntonis Kourtidis
May 2, 2020·Technology in Cancer Research & Treatment·Ling-Yu ChuXin-Xin Li
Apr 17, 2020·Micromachines·Jennifer QuinchiaJahir Orozco
Jul 20, 2018·Osong Public Health and Research Perspectives·Jae-Eun LeeYoung-Youl Kim
Apr 16, 2020·Trends in Analytical Chemistry : TRAC·Yu-Min WangWenwan Zhong
Jul 6, 2020·Human Antibodies·Nahal EshghifarFarkhondeh Pouresmaeili
Dec 4, 2020··Ammar Rasoul Mohammed. RudhaArshad Noori. G. AL-Dujaili

❮ Previous
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