Blood-based biomarkers for Down syndrome and Alzheimer's disease: A systematic review.

Developmental Neurobiology
Melissa E Petersen, Sid E O'Bryant

Abstract

Down syndrome (DS) occurs due to triplication of chromosome 21. Individuals with DS face an elevated risk for development of Alzheimer's disease (AD) due to increased amyloid beta (Aβ) resulting from the over-expression of the amyloid precursor protein found on chromosome 21. Diagnosis of AD among individuals with DS poses particular challenges resulting in an increased focus on alternative diagnostic methods such as blood-based biomarkers. The aim of this review was to evaluate the current state of the literature of blood-based biomarkers found in individuals with DS and particularly among those also diagnosed with AD or in prodromal stages (mild cognitive impairment [MCI]). A systematic review was conducted utilizing a comprehensive search strategy. Twenty-four references were identified, of those, 22 fulfilled inclusion criteria were selected for further analysis with restriction to only plasma-based biomarkers. Studies found Aβ to be consistently higher among individuals with DS; however, the link between Aβ peptides (Aβ1-42 and Aβ1-40) and AD among DS was inconsistent. Inflammatory-based proteins were more reliably found to be elevated leading to preliminary work focused on an algorithmic approach with predominantly inflam...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Aug 1, 1992·Journal of Intellectual Disability Research : JIDR·H M Evenhuis
May 1, 1992·Journal of the American Geriatrics Society·M Albert, C Cohen
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Z RahmaniA Aurias
Mar 20, 1998·Annals of Neurology·V P PrasherA C Butler
Apr 11, 2001·Neurology·T TapiolaT Pirttilä
Apr 9, 2005·Early Human Development·Jose L Bartha, Peter W Soothill
Feb 18, 2006·Behavior Genetics·Stefan J Teipel, Harald Hampel
Apr 21, 2006·Neurobiology of Aging·Marianna ZanaJános Kálmán
Dec 30, 2008·Neuroscience Letters·Emma L JonesClive G Ballard
Jun 11, 2009·International Journal of Geriatric Psychiatry·V P PrasherN Schupf
Jul 3, 2009·Alzheimer Disease and Associated Disorders·Elisa ContiCarlo Ferrarese
Jul 3, 2009·Alzheimer Disease and Associated Disorders·Yasuji MatsuokaPaul S Aisen
Oct 1, 2011·Neurobiology of Aging·Antonia M W CoppusCornelia M van Duijn
Jul 28, 2013·The Journal of Pediatrics·Angela P PressonEdward R B McCabe
Jul 16, 2014·Journal of Alzheimer's Disease : JAD·Sid E O'BryantPaula Grammas
Dec 2, 2014·Pediatric Clinics of North America·Kelly W MaloneyParesh Vyas
Sep 4, 2015·Journal of Proteome Research·Vincenzo BorelliManfred Wuhrer
Sep 24, 2015·Current Alzheimer Research·M Sabbagh, J Edgin
Jul 28, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·M Florencia IulitaA Claudio Cuello
Jul 28, 2016·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Sid E O'BryantNeill R Graff-Radford
Aug 12, 2016·Current Hematologic Malignancy Reports·Neha BhatnagarIrene Roberts
Oct 19, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Eric D HamlettAnn-Charlotte Granholm
Nov 3, 2016·Cardiovascular Journal of Africa·Sanaa BenhaourechAyoub El Hammiri
Dec 17, 2016·Journal of Alzheimer's Disease : JAD·Eric DoranIra T Lott
Dec 1, 2017·PloS One·Takashi KasaiTakahiko Tokuda
Apr 11, 2018·Alzheimer's Research & Therapy·Andre StrydomUNKNOWN LonDownS Consortium
Apr 15, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackUNKNOWN Contributors
Sep 11, 2018·Journal of Alzheimer's Disease : JAD·Sid E O'BryantRobert A Rissman
Feb 9, 2019·Nature Reviews. Neurology·Ira T Lott, Elizabeth Head

❮ Previous
Next ❯

Citations

Feb 13, 2020·Current Opinion in Psychiatry·Eimear McGlincheyMary McCarron
Dec 24, 2019·Frontiers in Aging Neuroscience·Xiaoyu DongDongming Zheng
Apr 8, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Mark MapstoneUNKNOWN Alzheimer's Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators
Aug 28, 2020·Frontiers in Aging Neuroscience·Ghazala IqbalTouqeer Ahmed
Jan 26, 2021·Journal of Alzheimer's Disease : JAD·Fan ZhangSid E O'Bryant
Aug 27, 2021·Frontiers in Aging Neuroscience·Sonia Do CarmoA Claudio Cuello

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Related Papers

Journal of Alzheimer's Disease : JAD
Sid E O'BryantTexas Alzheimer’s Research & Care Consortium
Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Annapaola PrestiaAlzheimer's Disease Neuroimaging Initiative
American Journal of Alzheimer's Disease and Other Dementias
Stuart M ZolaA I Levey
© 2021 Meta ULC. All rights reserved