Blood biomarkers for uveal melanoma.

Future Oncology
Pierre L Triozzi, Arun D Singh

Abstract

Uveal melanoma disseminates hematogenously, and blood biomarkers may be useful for prognosis and for monitoring disease progression. Melanoma-associated, metastatic and immune factors have been measured in the blood of patients with uveal melanoma, as have circulating melanoma cells. Most of the biomarkers were derived from studies in cutaneous melanoma. For various biological and/or technical reasons, these assessments have not demonstrated the accuracy required for effective prognostic or monitoring assays. Advances in uveal melanoma genomics and proteomics have generated many candidate biomarkers that are potentially measurable in blood. Measuring circulating nucleic acids may also be possible. Improvements in molecular profiling techniques that accurately predict metastatic risk in uveal melanoma patients should facilitate biomarker discovery and aid implementation in clinical testing. The stage is set to translate the advances made in understanding the molecular characteristics of uveal melanoma in order to identify and test clinically useful blood biomarkers of tumor dissemination and/or progression.

References

Jan 1, 1992·Documenta Ophthalmologica. Advances in Ophthalmology·M J JagerJ D'Amaro
May 4, 1996·Lancet·G PrescherR Becher
Jan 24, 1998·American Journal of Ophthalmology·G D HaynieL H Young
Jun 30, 2000·The British Journal of Ophthalmology·T G SheidowJ G Heathcote
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A C ReppJ Y Niederkorn
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R P SutmullerR Offringa
Feb 15, 2001·Microscopy Research and Technique·P EsserK Bartz-Schmidt
Oct 5, 2001·Japanese Journal of Ophthalmology·H GotoS Ito
Jun 18, 2002·Clinical & Experimental Metastasis·Elisabeth A SeftorMary J C Hendrix
Jun 26, 2003·Investigative Ophthalmology & Visual Science·Guy S MissottenMartine J Jager
Jul 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Devin DressmanBert Vogelstein
Aug 13, 2003·Archives of Ophthalmology·Guy S O A MissottenJohannes M G Bonfrer
Dec 4, 2003·Melanoma Research·Guy S MissottenJohannes M Bonfrer
Feb 5, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anja UlmerChristoph A Klein
May 13, 2004·British Journal of Cancer·S R Rittling, A F Chambers
May 28, 2004·Journal of Immunoassay & Immunochemistry·Asit K De, Sarah E Roach
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marie Diener-WestUNKNOWN Collaborative Ocular Melanoma Study Group Report 23
Jun 29, 2004·Journal of Surgical Oncology·John F ThompsonRichard A Scolyer
Oct 30, 2004·Current Eye Research·Subramanian KrishnakumarJyotirmay Biswas
Nov 24, 2004·Investigative Ophthalmology & Visual Science·Yu-Guang HeJerry Y Niederkorn
Mar 15, 2005·Ophthalmology Clinics of North America·Arun D Singh, Ernest C Borden
Apr 16, 2005·The Cancer Journal·Robert J McKenna
May 21, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·I W ReinigerA J Mueller
Jul 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shahid MianDirk Schadendorf
Oct 22, 2005·Nature Reviews. Cancer·Joseph A Ludwig, John N Weinstein
Dec 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Takuji MoriDave S B Hoon
Dec 31, 2005·Investigative Ophthalmology & Visual Science·Willem MaatMartine J Jager
Mar 1, 2006·Investigative Ophthalmology & Visual Science·Wieke ZuidervaartNelleke A Gruis
Mar 1, 2006·Investigative Ophthalmology & Visual Science·ShriHari S KadkolJacob Pe'er
Mar 7, 2006·The Journal of Biological Chemistry·Richard BauerAnja-Katrin Bosserhoff
Feb 1, 2007·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·G S MissottenJ M Bonfrer
Feb 23, 2007·International Journal of Cancer. Journal International Du Cancer·Maria DaniottiMonica Rodolfo
May 4, 2007·The British Journal of Ophthalmology·Arun D SinghBryan G Williams

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Methods Mentioned

BETA
genotyping
biopsy
PCR
gene array
chip

Software Mentioned

CellSearch

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