Blood Biomarkers of Late Pregnancy Exposure to Trihalomethanes in Drinking Water and Fetal Growth Measures and Gestational Age in a Chinese Cohort

Environmental Health Perspectives
Wen-Cheng CaoWen-Qing Lu

Abstract

Previous studies have suggested that elevated exposure to disinfection by-products (DBPs) in drinking water during gestation may result in adverse birth outcomes. However, the findings of these studies remain inconclusive. The purpose of our study was to examine the association between blood biomarkers of late pregnancy exposure to trihalomethanes (THMs) in drinking water and fetal growth and gestational age. We recruited 1,184 pregnant women between 2011 and 2013 in Wuhan and Xiaogan City, Hubei, China. Maternal blood THM concentrations, including chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), and bromoform (TBM), were measured as exposure biomarkers during late pregnancy. We estimated associations with gestational age and fetal growth indicators [birth weight, birth length, and small for gestational age (SGA)]. Total THMs (TTHMs; sum of TCM, BDCM, DBCM, and TBM) were associated with lower mean birth weight (-60.9 g; 95% CI: -116.2, -5.6 for the highest vs. lowest tertile; p for trend = 0.03), and BDCM and DBCM exposures were associated with smaller birth length (e.g., -0.20 cm; 95% CI: -0.37, -0.04 for the highest vs. lowest tertile of DBCM; p for trend = 0.02). SGA was increased in association wi...Continue Reading

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Citations

Oct 25, 2017·Journal of Exposure Science & Environmental Epidemiology·Stephanie GänglerDouglas W Dockery
Dec 7, 2019·Demography·Daniel S Grossman, David J G Slusky
Dec 19, 2019·Journal of Water and Health·Funanani MashauKuku Voyi
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Apr 27, 2021·The Science of the Total Environment·Fei-Peng CuiQiang Zeng
Aug 10, 2021·International Journal of Environmental Health Research·Xinyue PengWenjuan Zhang
Oct 8, 2021·Environmental Science & Technology·Yang SunCarmen Messerlian
Nov 24, 2021·Environmental Science & Technology·Chong LiuCarmen Messerlian

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Methods Mentioned

BETA
SGA

Software Mentioned

Predictive Analytics Suite Workstation ( PASW )

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