PMID: 2491756Jan 1, 1989Paper

Blood-brain barrier breakdown in cold-injured brain is linked to a biphasic stimulation of ornithine decarboxylase activity and polyamine synthesis: both are coordinately inhibited by verapamil, dexamethasone, and aspirin

Journal of Neurochemistry
H KoenigC Y Lu

Abstract

An early increase in ornithine decarboxylase (ODC) activity and polyamine levels in rat cerebral capillaries was previously implicated in the mediation of blood-brain barrier (BBB) breakdown in cold-injured brain. A time course study in rat cerebrum indicated that cold injury evokes a biphasic increase in ODC activity and polyamine levels in perilesional cortex. ODC activity rose sharply (fourfold) within 1 min, remained elevated for 5 min, and then returned to the basal level by 10 min. A transient rise in polyamine concentration followed in the rank order of putrescine greater than spermidine greater than spermine. A secondary rise in ODC activity commenced in perilesional tissue at 2-6 h and peaked (8.8-fold) at 48 h. Major increases in the content of putrescine (330%), spermidine (103%), and spermine (50%) developed at 48-72 h. alpha-Difluoromethylornithine (DFMO), a specific irreversible inhibitor of ODC, suppressed the evoked increase in ODC activity and abolished the associated increase in content of polyamines, findings indicating that the accumulation of polyamines in cryoinjured brain reflects enhanced synthesis resulting from an ODC-mediated increase in putrescine content. Cycloheximide and actinomycin D were without...Continue Reading

References

May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S L Hong, L Levine
Sep 1, 1988·Journal of Molecular and Cellular Cardiology·C C Fan, H Koenig
Dec 1, 1986·Circulation Research·R C KukrejaE F Ellis
Apr 1, 1986·Annals of Neurology·E T Hedley-Whyte, D W Hsu
Jan 1, 1972·Pflügers Archiv : European journal of physiology·M KohlhardtA Fleckenstein
Jul 1, 1970·Archives of Neurology·H M EisenbergA V Lorenzo
Feb 1, 1969·Archives of Neurology·H M Pappius, W P McCann
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E A NeuweltE P Frenkel
Jan 1, 1983·Neurochemical Research·H M Pappius, L S Wolfe
Nov 15, 1983·Biochemical and Biophysical Research Communications·H KoenigC Y Lu
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H KoenigC Y Lu
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·F HirataJ Axelrod

❮ Previous
Next ❯

Citations

Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K D KaitaG Y Minuk
Jan 1, 1991·Neuroradiology·J Greenwood
Jun 1, 1992·Molecular and Chemical Neuropathology·W Paschen
Nov 26, 2011·Clinical Reviews in Allergy & Immunology·Wesley H Brooks
Jan 1, 1991·Life Sciences·E MartínezF Artigas
Jan 1, 1990·Pharmacology, Biochemistry, and Behavior·P A Ferchmin, V A Eterović
Feb 19, 1993·Brain Research. Developmental Brain Research·E Ciani, A Contestabile
Jan 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·B Peruche, J Krieglstein
Feb 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·F FacchinettiA Contestabile
Dec 9, 2009·Journal of Neurotrauma·Kamyar ZahediKenneth I Strauss
Apr 1, 1992·Neuropathology and Applied Neurobiology·J V LafuenteJ Cervos-Navarro
Aug 3, 2006·Mediators of Inflammation·Christopher Bolton, Carolyn Paul
Dec 1, 1990·Journal of Neurosurgery·M KiesslingH R Eggert
Sep 1, 1996·Journal of Neurosurgery·S A BaldwinS W Scheff
Mar 25, 2014·American Journal of Human Genetics·Daniel WooUNKNOWN International Stroke Genetics Consortium
Mar 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W PaschenG Röhn
Nov 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M S KindyR J Dempsey
Nov 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R J DempseyM S Kindy
Jan 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J A Yergey, M P Heyes
Nov 9, 2017·Stroke; a Journal of Cerebral Circulation·Guido J Falcone, Daniel Woo
Dec 7, 2018·International Journal of Molecular Sciences·Yi-Chun ChenChiung-Mei Chen
Feb 1, 1993·Journal of Neurochemistry·R I ErnestusW Paschen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.