Blood-brain barrier disruption by low-frequency ultrasound

Stroke; a Journal of Cerebral Circulation
Matthias ReinhardThomas Els

Abstract

A recent study showed a dramatic increase in cerebral hemorrhage comprising atypical locations with low-frequency ultrasound-mediated recombinant tissue plasminogen activator-thrombolysis in humans. Here, we provide a possible explanation for this phenomenon by a side effect observed in a study using the similar ultrasound device. The study was originally undertaken to investigate by transcranial Doppler sonography, positron emission tomography and perfusion MRI whether transcranial application of wide-field low-frequency ultrasound (300 kHz) improves cerebral hemodynamics in patients with cerebral small vessel disease. Showing no clear positive effect on cerebral hemodynamics in 4 patients and on cerebral perfusion (positron emission tomography) in 2 patients, the study has been terminated early because of a remarkable side effect in the first patient (a 62 year-old man) undergoing perfusion-MRI: detection of frontoparietal extravasation of Gadolinium contrast agent (applied during MRI perfusion imaging preinsonation) on MRI immediately postinsonation. Abnormal permeability of the human blood-brain barrier can be induced by wide-field low-frequency insonation. The observed excessive bleeding rate with low-frequency sonothrombo...Continue Reading

References

Mar 8, 2003·Stroke; a Journal of Cerebral Circulation·J M WardlawJ Starr
Aug 18, 2004·Ultrasound in Medicine & Biology·Nickolai SheikovKullervo Hynynen
Oct 7, 2004·Journal of the American College of Cardiology·Robert J SiegelCharles W Francis
Nov 19, 2004·The New England Journal of Medicine·Andrei V AlexandrovUNKNOWN CLOTBUST Investigators

❮ Previous
Next ❯

Citations

Aug 1, 2007·Journal of Thrombosis and Thrombolysis·David SkoloudíkPetr Kanovský
Feb 5, 2013·Current Treatment Options in Neurology·Kristian Barlinn, Andrei V Alexandrov
Sep 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·James J ChoiElisa E Konofagou
Oct 17, 2009·Neurosurgery·Ricky MedelNeal F Kassell
Nov 7, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Petr BardonDavid Skoloudik
Apr 29, 2010·Current Cardiology Reports·Clotilde Balucani, Andrei V Alexandrov
May 25, 2012·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Andrei V Alexandrov, Kristian Barlinn
Feb 11, 2011·Expert Review of Neurotherapeutics·Alexandre Amaral-SilvaCarlos A Molina
Jan 10, 2014·Expert Opinion on Drug Delivery·Marie de Saint VictorEleanor Stride
Apr 5, 2013·Expert Opinion on Drug Delivery·Ying-Zheng ZhaoJun Cai
Jul 14, 2010·Ultrasound in Medicine & Biology·David SkoloudíkRoman Herzig
Aug 6, 2010·Brain Research Reviews·Filipa Lourenço CardosoMaria Alexandra Brito
Jun 24, 2009·Ultrasound in Medicine & Biology·Kristin Frinkley BingKathryn R Nightingale
Apr 28, 2009·Ultrasound in Medicine & Biology·Cecile BaronMathias Fink
Apr 21, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Eunice E ChoKullervo Hynynen
Aug 30, 2008·Ultrasound in Medicine & Biology·Max NedelmannTibo Gerriets
May 6, 2008·Ultrasound in Medicine & Biology·Azzdine Y AmmiChristy K Holland
May 20, 2008·Advanced Drug Delivery Reviews·Kullervo Hynynen
May 31, 2008·Ultrasonics·Georgios TsivgoulisAndrei V Alexandrov
Oct 19, 2007·Thrombosis Research·Michael D TornoAxel J Rosengart
Sep 15, 2007·Ultrasound in Medicine & Biology·Gerhard J JungehulsingStephan J Schreiber
May 6, 2010·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Takashi AzumaHiroshi Furuhata
Sep 30, 2010·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Nathan McDannoldFerenc Jolesz
Jun 18, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Pooja Gaur, William A Grissom
Apr 11, 2017·Expert Opinion on Pharmacotherapy·Brandon R ChristopheE Sander Connolly
Apr 27, 2012·Stroke; a Journal of Cerebral Circulation·Stephen MeairsMichael G Hennerici
Dec 16, 2006·Stroke; a Journal of Cerebral Circulation·Tibo GerrietsManfred Kaps
Jan 2, 2010·Stroke; a Journal of Cerebral Circulation·Georgios TsivgoulisAndrei V Alexandrov
Apr 20, 2013·Stroke; a Journal of Cerebral Circulation·Kristian BarlinnAndrei V Alexandrov
Feb 3, 2007·Stroke; a Journal of Cerebral Circulation·Thomas Wilhelm-SchwenkmezgerMax Nedelmann
Mar 15, 2008·Stroke; a Journal of Cerebral Circulation·Georgios Tsivgoulis, Andrei Alexandrov
Mar 21, 2020·Journal of Clinical Medicine·Jens EydingChristos Krogias
May 29, 2021·Ultrasound in Medicine & Biology·Francesco PradaChristoph Dietrich

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.