Blood-brain barrier dysfunction following traumatic brain injury: correlation of K(trans) (DCE-MRI) and SUVR (99mTc-DTPA SPECT) but not serum S100B

Neurological Research
Craig WinterStephen Rose

Abstract

Damage to the blood-brain barrier (BBB) is an important secondary mechanism that occurs following traumatic brain injury (TBI) and may provide a potential therapeutic target to improve patient outcome. For such a progress to be realised, an accurate assessment of BBB compromise needs to be established. Fourteen patients with TBI were prospectively recruited. Post-traumatic BBB dysfunction was assessed using dynamic contrast-enhanced MRI (DCE-MRI), single-photon emission computerised tomography (SPECT) and serum S100B levels. A statistically significant correlation between standardised uptake value ratio (SUVR) calculated from 99mTc-DTPA SPECT and K(trans) (a volume transfer constant) from DCE-MRI was found for those eight patients who had concurrent scans. The positive correlation persisted when the data were corrected for patient age, number of days following trauma and both parameters combined. We found no statistically significant correlation between either of the imaging modalities and concurrent serum S100B levels. The correlation of SPECT with DCE-MRI suggests that either scan may be used to assess post-traumatic BBB damage. We could not support serum S100B to be an accurate measure of BBB damage when sampled a number of ...Continue Reading

References

Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P S Tofts, A G Kermode
Jan 1, 1995·Brain Research Bulletin·D B ZimmerW Song
Jan 4, 2001·Journal of Cardiothoracic and Vascular Anesthesia·H JönssonS Blomquist
Mar 10, 2001·Journal of the Neurological Sciences·H Reiber, J B Peter
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·G GhanemUNKNOWN EORTC Melanoma Group
May 22, 2002·Brain Research·M KapuralD Janigro
Aug 12, 2003·Brain Research Bulletin·A PetzoldE J Thompson
Jun 29, 2004·Lancet·Charles MockFrederick Rivara
Feb 4, 2005·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Akira KornAlon Friedman
Aug 25, 2006·Journal of Neurotrauma·Andrea Kleindienst, M Ross Bullock
Sep 30, 2006·Stroke; a Journal of Cerebral Circulation·Pilar DelgadoJoan Montaner
May 25, 2007·Neurocritical Care·Stephen M BloomfieldJonathan Brisman
Apr 23, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Eugene ParkAndrew J Baker
Jul 19, 2008·Lancet Neurology·Andrew I R MaasRoss Bullock
Oct 10, 2008·Seminars in Neurology·Joseph C Masdeu, Javier Arbizu
Mar 5, 2009·Journal of Neurotrauma·Brian J BlythJeffrey J Bazarian
Jun 17, 2010·Nature Reviews. Neurology·Dan ShlosbergAlon Friedman
Oct 16, 2010·Neuropathology and Applied Neurobiology·S NagD J Stewart
Oct 30, 2010·Magnetic Resonance Imaging·Paul A ArmitageJoanna M Wardlaw
Mar 5, 2011·Clinical Radiology·C McArthurD Hadley
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Feb 11, 2012·Journal of Neurology·Ronit GiladMordechai Loyberboim
May 15, 2012·Journal of Magnetic Resonance Imaging : JMRI·Na ZhangBob L Hou
Jun 12, 2012·Brain Imaging and Behavior·A P LinB D Ross
Nov 20, 2012·Neurologia i neurochirurgia polska·Serap DuruSadık Ardıç
Mar 14, 2013·PloS One·Nicola MarchiDamir Janigro
Jun 8, 2013·Stroke; a Journal of Cerebral Circulation·Hua-Shan LiuCheng-Yu Chen
Aug 21, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xiao-Er WeiWen-Bin Li
Nov 30, 2006·The Neuroradiology Journal·W MarksM Stasiak

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Citations

Jan 16, 2016·Oxidative Medicine and Cellular Longevity·Ji JiaTingting Huo
May 18, 2016·Neuroscience and Biobehavioral Reviews·Keisuke KawataDianne Langford
Jun 9, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·James H Cole

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