Blood-Brain Barrier Dysfunction in Idiopathic Intracranial Hypertension

Journal of Neuropathology and Experimental Neurology
Md Mahdi Hasan-OlivePer Kristian Eide

Abstract

Idiopathic intracranial hypertension (IIH) is traditionally considered benign and characterized by symptoms related to increased intracranial pressure, including headache and impaired vision. We have previously demonstrated that brains of IIH patients exhibit patchy astrogliosis, increased perivascular expression of the water channel aquaporin-4 (AQP4) as well as degenerating pericyte processes and capillary basement membranes. Given the established association between pericyte degeneration and blood-brain barrier (BBB) dysfunction, we investigated blood protein leakage by light microscopic immunohistochemistry. We also assessed perivascular AQP4 expression by immunogold transmission electron microscopy. The study included 14 IIH patients and 14 reference (REF) subjects undergoing neurosurgery for epilepsy, aneurysm, or tumor. Evidence of BBB dysfunction, measured as area extravasated fibrinogen/fibrin, was significantly more pronounced in IIH than REF individuals. The extent of extravasated fibrinogen was positively correlated with increasing degree of astrogliosis and vascular AQP4 immunoreactivity, determined by light microscopy. Immunogold transmission electron microscopy revealed no overall changes in AQP4 expression at as...Continue Reading

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Citations

Nov 27, 2019·Fluids and Barriers of the CNS·Sajedeh EftekhariRigmor Hoejland Jensen
Mar 7, 2020·Fluids and Barriers of the CNS·Richard F KeepLester R Drewes
Jul 9, 2021·Brain Communications·Per Kristian EideLars Magnus Valnes
Jul 1, 2021·Neuropediatrics·Hans C LudwigSteffi Dreha-Kulaczewski
Oct 12, 2021·The Journal of Headache and Pain·Connar Stanley James WestgateSajedeh Eftekhari

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