Blood-brain barrier permeability changes during acute allergic encephalomyelitis induced in the guinea pig

Metabolic Brain Disease
B V ZlokovicH Davson

Abstract

Blood-brain barrier permeability to homologous serum 125I-IgG and to D-[3H]mannitol was studied by means of the brain vascular perfusion method in guinea pigs with experimental allergic encephalomyelitis (EAE). EAE was induced with homologous myelin basic protein (MBP) after pretreatment with foreign protein and muramyl dipeptide (MDP). The results suggest a significant comparable increase in IgG blood-to-brain clearance in the parietal cortex, hippocampus, and caudate nucleus, during vascular perfusion of the brains of animals, after 7 and 20 days of EAE. On the other hand, unidirectional transfer of mannitol in the same period of EAE was markedly augmented only in the hippocampus, but no significant changes in the parietal cortex or caudate nucleus were observed. Cerebrospinal fluid (CSF)/serum ratios for IgG and albumin were both significantly increased, suggesting an increase in blood-CSF barrier permeability, but more for albumin than for IgG. The results were confirmed by immunohistochemical determination of the IgG deposits in the brains of EAE animals, during vascular perfusion with unlabeled homologous IgG. An important role of the blood-brain barrier for the central nervous system immunoglobulin homeostasis during EAE...Continue Reading

Citations

Mar 19, 2013·Journal of Molecular Neuroscience : MN·Hung HsuchouWeihong Pan
Jul 23, 2014·Acta Neuropathologica Communications·Francesco GirolamoMaria Trojano
Feb 11, 2012·Journal of Proteome Research·Therese RosenlingTheo M Luider
Dec 22, 2009·Neurosurgery·Leonardo Deus-SilvaMarlise P dos Santos
Jan 30, 2013·Neurologia Medico-chirurgica·Tomonori IwataMasahito Nakazaki

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