Blood-brain barrier permeability during the development of experimental bacterial meningitis in the rat

Experimental Neurology
K S KimA S Cross

Abstract

In an attempt to examine whether routes of bacterial entry into the central nervous system have any bearing on subsequent changes in blood-brain barrier permeability, we examined cerebrospinal fluid (CSF) penetration of circulating 125I-albumin in two different models of experimental meningitis due to K1 Escherichia coli, type III group B streptococcus, or Haemophilus influenzae type b in infant rats: hematogenous meningitis subsequent to subcutaneous inoculation of bacteria vs meningitis induced by direct inoculation of bacteria into the CSF via the cisterna magna. In the model of hematogenous meningitis, the mean CSF penetration was significantly greater in animals with H. influenzae type b meningitis than in those with meningitis due to K1 E. coli or type III group B streptococcus. In contrast, the mean CSF penetration was significantly enhanced in all animals with meningitis induced by intracisternal inoculation regardless of infecting pathogens. Tumor necrosis factor activity in CSF appeared to correlate with the functional penetration of circulating albumin across the blood-brain barrier in both models of experimental meningitis. These findings suggest that the alterations of blood-brain barrier permeability during develo...Continue Reading

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Citations

Sep 23, 2008·Expert Reviews in Molecular Medicine·Heather C MaiseyVictor Nizet
Nov 9, 2002·The Journal of Infectious Diseases·Kwang Sik Kim
Aug 14, 2001·Infection and Immunity·K S Kim
Jun 24, 2003·Archives of Disease in Childhood·N PathanM Levin
Nov 29, 2013·Toxins·Ming-Hsien Wang, Kwang Sik Kim
Mar 8, 2012·Future Microbiology·Nina M van Sorge, Kelly S Doran
Sep 4, 2010·Clinics in Perinatology·Denis Grandgirard, Stephen L Leib
Jan 1, 2008·The Journal of Surgical Research·Stefan HoferMarkus A Weigand
Feb 14, 2006·Biochemical and Biophysical Research Communications·Maneesh Paul-SatyaseelaKwang Sik Kim
Apr 2, 2003·Expert Opinion on Therapeutic Targets·Kwang Sik Kim
Feb 3, 2018·Journal of Neurosurgery·Ewa Szczepek, Waldemar Koszewski
Dec 12, 2018·The Journal of Antimicrobial Chemotherapy·Alexia ChauzyPascal Chavanet
May 3, 2003·Nature Reviews. Neuroscience·Kwang Sik Kim
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·J D HuberT P Davis
Sep 3, 1999·Antimicrobial Agents and Chemotherapy·N TsaoH Y Lei
May 26, 2016·EcoSal Plus·Kwang Sik Kim
May 3, 2003·Methods : a Companion to Methods in Enzymology·E A Eugenin, Joan W Berman
Jan 1, 2006·EcoSal Plus·Kwang Sik Kim
Aug 26, 2003·Advanced Drug Delivery Reviews·Anne M WolkaThomas P Davis

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