PMID: 6160732Apr 1, 1980Paper

Blood-brain barrier selectivity and synaptic turnover during delirium tremens and related clinical states. A study of brain and blood proteins in the cerebrospinal fluid

Acta Psychiatrica Scandinavica
O S JørgensenO J Rafaelsen

Abstract

The synaptic membrane protein D2 was measured in the cerebrospinal fluid (CSF) from patients with delirium tremens and related clinical states immediately after admission to the hospital before treatment was initiated and again after recovery. during this period of on average 5 days duration the concentration of D2 increased to double normal value possible indicating increased breakdown of old synapses during the process of readaptation to the alcohol free state. IgG, albumin and alpha 2-macroglobulin were measured in plasma and in CSF and the results indicated a decreased selectivity of blood-CSF-barrier permeability to proteins in the clinically recovered patients; this was probably due to increased micropinocytotic activity also occurring during readaptation to the alcohol free state.

References

Apr 1, 1979·Acta Psychiatrica Scandinavica·R HemmingsenO J Rafaelsen
Jul 1, 1977·Acta Psychiatrica Scandinavica·O S JorgensenO J Rafaelsen
Aug 1, 1978·Acta Psychiatrica Scandinavica·P Kramp, O J Rafaelsen
Mar 1, 1979·Acta Psychiatrica Scandinavica·P KrampT Hansen
Nov 1, 1979·Acta Psychiatrica Scandinavica·P Kramp, R Hemmingsen
Nov 1, 1979·Acta Psychiatrica Scandinavica·P KrampO J Rafaelsen
Oct 1, 1974·Journal of Neurochemistry·O S Jorgensen, E Bock
Jan 1, 1973·Scandinavian Journal of Immunology. Supplement·B Weeke
Sep 1, 1980·Psychiatry Research·R Hemmingsen, O S Jørgensen
Nov 1, 1976·Journal of Neurochemistry·O S Jørgensen

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Citations

Dec 1, 1990·Italian Journal of Neurological Sciences·A R MassaroP Tonali
Sep 1, 1980·Psychiatry Research·R Hemmingsen, O S Jørgensen
May 17, 2008·Neurochemical Research·Thomas Secher
Jan 1, 1982·Scandinavian Journal of Immunology. Supplement·E BockM Treiman
Sep 21, 1981·Brain Research·O S Jørgensen, M Møller
Oct 1, 1981·Journal of Neurochemistry·O S Jørgensen
Feb 1, 1990·Alcoholism, Clinical and Experimental Research·D J Bonthius, J R West
Jan 1, 1988·Acta Psychiatrica Scandinavica. Supplementum·O S Jørgensen

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