Blood-brain barrier transport and brain metabolism of glucose during acute hyperglycemia in humans

The Journal of Clinical Endocrinology and Metabolism
S HasselbalchO B Paulson

Abstract

It is controversial whether transport adaptation takes place in chronic or acute hyperglycemia. Blood-brain barrier glucose permeability and regional brain glucose metabolism (CMR(glc)) was studied in acute hyperglycemia in six normal human subjects (mean age, 23 yr) using the double indicator method and positron emission tomography and [(18)F]fluorodeoxyglucose as tracer. The Kety-Schmidt technique was used for measurement of cerebral blood flow (CBF). After 2 h of hyperglycemia (15.7 +/- 0.7 mmol/L), the glucose permeability-surface area product from blood to brain remained unchanged (0.050 +/- 0.008 vs. 0.059 +/- 0.031 mL/100 g.min). The unidirectional clearance of [(18)F]fluorodeoxyglucose (K(1)*) was reduced from 0.108 +/- 0.011 to 0.061 +/- 0.005 mL/100 g.min (P < 0.0004). During hyperglycemia, global CMR(glc) remained constant (21.4 +/- 1.2 vs. 23.1 +/- 2.2 micromol/100 g.min, normo- and hyperglycemia, respectively). Except for a significant increase in white matter CMR(glc), no regional difference in CMR(glc) was found. Likewise, CBF remained unchanged. The reduction in K(1)* was compatible with Michaelis-Menten kinetics for facilitated transport. Our findings indicate no major adaptational changes in the maximal transp...Continue Reading

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Citations

Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Myriam M ChaumeilVincent Lebon
May 10, 2012·The Journal of Pharmacology and Experimental Therapeutics·Aisha I Kelly-CobbsAdviye Ergul
Oct 18, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Joseph A ThieKarl F Hubner
Dec 7, 2007·Physiology & Behavior·Ping Wang, Edwin C M Mariman
Feb 27, 2010·Annals of Neurology·Cigdem I AkmanDarryl C De Vivo
Dec 11, 2008·Pediatric Diabetes·John I MaloneDavid M Diamond
Apr 23, 2015·European Radiology·Georgia KeramidaA Michael Peters
Dec 4, 2014·Intensive Care Medicine·Romain SonnevilleGreet Van den Berghe

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