Blood cell interactions and segregation in flow

Annals of Biomedical Engineering
Lance L Munn, Michael M Dupin

Abstract

For more than a century, pioneering researchers have been using novel experimental and computational approaches to probe the mysteries of blood flow. Thanks to their efforts, we know that blood cells generally prefer to migrate to the axis of flow, that red and white cells segregate in flow, and that cell deformability and their tendency to reversibly aggregate contribute to the non-Newtonian nature of this unique fluid. All of these properties have beneficial physiological consequences, allowing blood to perform a variety of critical functions. Our current understanding of these unusual flow properties of blood have been made possible by the ingenuity and diligence of a number of researchers, including Harry Goldsmith, who developed novel technologies to visualize and quantify the flow of blood at the level of individual cells. Here we summarize efforts in our lab to continue this tradition and to further our understanding of how blood cells interact with each other and with the blood vessel wall.

References

Jun 10, 1977·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T Karino, H L Goldsmith
Sep 1, 1978·Microvascular Research·T S DewitzL V McIntire
Jan 1, 1975·Circulation Research·G W Schmid-SchoenbeinB W Zweifach
Sep 21, 1992·Journal of Theoretical Biology·C Dong, R Skalak
Nov 1, 1989·The American Journal of Physiology·A J Moe, C H Smith
Jan 1, 1988·Advances in Experimental Medicine and Biology·H H LipowskyJ C Firrell
Nov 1, 1987·Microvascular Research·S D House, H H Lipowsky
Jan 1, 1987·Annals of the New York Academy of Sciences·T KarinoY Sohara
Jan 1, 1987·Annals of the New York Academy of Sciences·H L Goldsmith, T Karino
Jan 1, 1986·Journal of Cellular Biochemistry·E C ButcherS Jalkanen
Jan 1, 1987·Microvascular Research·H N MayrovitzR N Sampsell
Jul 1, 1973·Microvascular Research·S K Yu, H L Goldsmith
Mar 1, 1984·Microvascular Research·H L Goldsmith, S Spain
Jan 1, 1980·Microvascular Research·G W Schmid-SchönbeinS Chien
Dec 15, 1996·The Journal of Clinical Investigation·K Konstantopoulos, L V McIntire
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M J Pearson, H H Lipowsky
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J J BishopP C Johnson
Jan 6, 2001·Annals of Biomedical Engineering·A R Pries, T W Secomb
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J J BishopP C Johnson
Jun 8, 2002·Annals of Biomedical Engineering·Scott I Simon, Harry L Goldsmith
Sep 27, 2002·Biophysical Journal·Cristiano MiglioriniLance L Munn
Jan 1, 1958·Journal of Applied Physiology·A D MAUDE, R L WHITMORE
Feb 1, 2005·Analytical Chemistry·Sergey S ShevkoplyasMark W Bitensky
Mar 24, 2007·Annals of Biomedical Engineering·Timothy W SecombAxel R Pries
Aug 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Michael M DupinLance L Munn
Aug 18, 1967·Science·S ChienM I Gregersen
Aug 18, 1967·Science·S ChienM M Guest
Apr 9, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Dai FukumuraRakesh K Jain

❮ Previous
Next ❯

Citations

Apr 7, 2012·Annals of Biomedical Engineering·Weiwei Wang, Michael R King
Apr 24, 2010·Medical & Biological Engineering & Computing·Ali Asgar S BhagatChwee Teck Lim
Sep 4, 2012·Antioxidants & Redox Signaling·Pedro Cabrales
Jan 8, 2014·Biomicrofluidics·Hsieh ChenAlfredo Alexander-Katz
Jan 7, 2014·Respiratory Physiology & Neurobiology·Yong Wang, S Elghobashi
Jul 4, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Pedro Cabrales, Marcos Intaglietta
Apr 28, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·C Makena HightowerMarcos Intaglietta
Aug 13, 2014·Artificial Organs·Hemant MisraAbraham Abuchowski
Apr 2, 2014·AAPS PharmSciTech·Erik CarboniAnson W K Ma
Oct 6, 2016·Biophysical Journal·Erik J CarboniAnson W K Ma
Oct 16, 2016·Biomechanics and Modeling in Mechanobiology·L L XiaoB M Fu
Dec 13, 2016·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Lance L Munn
Jan 19, 2018·SLAS Technology·Charles LissandrelloJason Fiering
Mar 10, 2016·Journal of Biomedical Optics·Kisung LeeAndrey A Fedyanin
Apr 7, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ken-ichi Tsubota, Shigeo Wada
Feb 7, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Amit Kumar, Michael D Graham
May 18, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Yuta Kataoka, Takaji Inamuro
Oct 16, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Jason P GleghornBrian J Kirby
Aug 15, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Hongzhi Lan, Damir B Khismatullin
Jul 19, 2019·Pharmaceutics·Arnau BioscaXavier Fernàndez-Busquets
Jul 28, 2020·Advanced Science·Xiaoshuai LiuBaojun Li
Jun 9, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Hiromi SakaiEishun Tsuchida
Aug 19, 2011·Lab on a Chip·Xiaoxi YangSergey S Shevkoplyas
Mar 18, 2016·Physical Review. E·Marmar MehrabadiCyrus K Aidun
Aug 17, 2019·Frontiers in Physiology·Virginia PretiniRichard Van Wijk
Oct 11, 2021·International Journal of Pharmaceutics·Raul Diaz-SalmeronKawthar Bouchemal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

© 2021 Meta ULC. All rights reserved