Blood cell transcriptomic-based early biomarkers of adverse programming effects of gestational calorie restriction and their reversibility by leptin supplementation

Scientific Reports
Jadwiga KoniecznaA Palou

Abstract

The challenge of preventing major chronic diseases requires reliable, early biomarkers. Gestational mild undernutrition in rats is enough to program the offspring to develop later pathologies; the intake of leptin, a breastmilk component, during lactation may reverse these programming effects. We used these models to identify, in peripheral blood mononuclear cells (PBMCs), transcriptomic-based early biomarkers of programmed susceptibility to later disorders, and explored their response to neonatal leptin intake. Microarray analysis was performed in PBMCs from the offspring of control and 20% gestational calorie-restricted dams (CR), and CR-rats supplemented with physiological doses of leptin throughout lactation. Notably, leptin supplementation normalised 218 of the 224 mRNA-levels identified in PBMCs associated to undernutrition during pregnancy. These markers may be useful for early identification and subsequent monitoring of individuals who are at risk of later diseases and would specifically benefit from the intake of appropriate amounts of leptin during lactation.

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Citations

Dec 29, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·N SzostaczukC Picó
Jun 7, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J SánchezA Palou
Aug 8, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bàrbara ReynésAndreu Palou
Oct 5, 2018·Nutrition Reviews·Mariona PalouAndreu Palou
Dec 23, 2020·European Journal of Clinical Investigation·Catalina PicóPaulo Matafome
Jul 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Bàrbara ReynésAndreu Palou
Feb 9, 2021·Molecular Nutrition & Food Research·Pedro CastilloCatalina Picó

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Methods Mentioned

BETA
gene array
chips
Feature Extraction
PCR

Software Mentioned

Babelomics
SPSS Statistics
R
Feature Extraction
StepOne
R Development Core Team
limma
Bioconductor

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