PMID: 3765352Jun 1, 1986Paper

Blood changes in carp (Cyprinus carpio) induced by ulcerative Aeromonas salmonicida infections

Veterinary Immunology and Immunopathology
D EvenbergWillem B van Muiswinkel

Abstract

Only recently Aeromonas salmonicida has been recognized as a significant bacterial pathogen in ulcerative disease of cyprinid fish. Our attempts to formulate a vaccine based on bacterial surface antigens were unsuccessful in conferring reliable protection against lethal challenge. This lead us to study pathological changes in the humoral defense system during ulcerative A. salmonicida infection in carp. High numbers of opportunist pathogens such as A. hydrophila and Pseudomonas sp. were frequently recovered from the internal organs of moribund fish, in addition to A. salmonicida. These findings together with leucopenia in moribund fish suggest that pathogenesis is characterized by a state of immune suppression. In addition, fish which had sustained a sublethal infection were not protected against a subsequent lethal challenge. However, fish previously injected with a concentrated and inactivated culture supernatant showed protection. Differential blood cell counts did not differ between experimental and control groups during sublethal infection in contrast to serum proteins. Furthermore infected non-immune carp showed a progressive decrease of immunoglobulin and total serum protein levels before the day of peak mortality wherea...Continue Reading

Citations

Nov 5, 2008·Fish Physiology and Biochemistry·D ShahsavaniH Gholipour Kanani
Jan 1, 1990·Developmental and Comparative Immunology·J F SövényiR Kusuda
Nov 1, 1995·Veterinary Immunology and Immunopathology·B MagnadóttirB K Gudmundsdóttir
Jul 28, 2011·Veterinary Clinical Pathology·Nicholas M OtwayRod Starr
Feb 16, 2006·Fish & Shellfish Immunology·Heidi B T HuttenhuisJan H W M Rombout
Jul 1, 1991·Gut·G J PostonP J Guillou
Oct 6, 1990·BMJ : British Medical Journal·L O Simpson
Jul 31, 2012·Journal of Aquatic Animal Health·Maria S SepúlvedaTrent M Sutton
Sep 22, 2005·Veterinary Immunology and Immunopathology·Moti DrorRamy R Avtalion

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