Blood coagulation equilibrium in rat liver microcirculation as evaluated by endothelial cell thrombomodulin and macrophage tissue factor

Thrombosis Research
M AraiK Fujiwara

Abstract

The regulatory mechanisms of microcirculation might differ in the liver from other organs, because macrophages are resident in the hepatic sinusoids and sinusoidal endothelial cells are unique in shape and function. Thrombomodulin expression in endothelial cells and tissue factor activity in isolated macrophages were studied in the liver and lung of rats. In normal rats, the thrombomodulin expression was minimal in hepatic sinusoids, but prominent in pulmonary capillaries, while the tissue factor activity in the presence of endotoxin was higher in pulmonary macrophages than in Kupffer cells, although the levels in the absence of endotoxin were comparable in both cells. The tissue factor activity in hepatic macrophages was increased after priming of the cells with Corynebacterium parvum or after induction of liver necrosis or cirrhosis with carbon tetrachloride. In the necrotic or cirrhotic liver, increased thrombomodulin expression was seen along capillaries extending in necrotic areas and regenerating nodules, but this increase was minimal in the Corynebacterium parvum-treated rat liver. Blood coagulation equilibrium in microcirculation regulated by endothelial cells and macrophages may differ between the liver and lung. Such ...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jun 1, 1981·American Journal of Clinical Pathology·S M HsuH Fanger
Mar 1, 1963·Gastroenterology·F SCHAFFNER, H POPER
Jul 1, 2006·Stroke; a Journal of Cerebral Circulation·Jan T KielsteinStefanie M Bode-Böger

❮ Previous
Next ❯

Citations

Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M AraiK Fujiwara
Jan 31, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·James P LuyendykRuipeng Wang
May 9, 2012·World Journal of Gastroenterology : WJG·Masayuki MiyazakiRyoichi Takayanagi
Jul 12, 2002·Journal of Gastroenterology·Kenji Fujiwara, Satoshi Mochida
Nov 6, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takeshi NowatariNobuhiro Ohkohchi
Jan 28, 2010·Acta Biomaterialia·John T WilsonElliot L Chaikof
Mar 13, 2012·Journal of Applied Toxicology : JAT·Mohamed A HammadMohammad K Ashfaq
Jan 8, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Márcia Barbosa AguilaCarlos Alberto Mandarim-de-Lacerda
May 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W CuiE L Chaikof
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S MochidaK Fujiwara
Apr 13, 2013·Cardiovascular and Interventional Radiology·Dirk SchnapauffBernhard Gebauer
May 21, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·M S Abdel-BakkyA S Saad
Sep 1, 1998·Journal of Gastroenterology and Hepatology·Keiko ToshimaKenji Fujiwara
Aug 28, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Mohamed Sadek Abdel-BakkyAhmed Saad Saad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.