PMID: 765611Dec 15, 1975

Blood coagulation factor XIII and fibrin stabilization (author's transl)

Klinische Wochenschrift
H Rasche

Abstract

Coagulation factor XIII (fibrin stabilizing factor, FSF) is detectable in plasma, platelets, placenta and various tissues. In the activated form FSF has the enzymatic properties of a transglutaminase and is capable of stabilizing fibrin by inducing covalent bondings between fibrin monomers. In patients with congenital factor XIII deficiency or acquired immune inhibitors of fibrin stabilization a severe bleeding tendency is evident. There is not yet enough information available concerning the significance of reduced FSF-activity as cofactor in hemorrhagic diathesis and wound healing disturbances in various disease states. There are some indications from experimental studies that there might be an influence of FSF on tumor growth and metastasis as well as arteriosclerosis. The quantitation of the enzyme by radiological and immunological techniques yield reproducible results. Fibrin in its stabilized or non stabilized form can be discriminated in polyacrylamide gel electrophoresis after reduction of fibrin clots.

References

Mar 1, 1975·Blut·H Rasche, M Dietrich
Oct 1, 1973·The Journal of Clinical Investigation·E D IsraelsL G Israels
Jan 1, 1974·Acta Haematologica·K MiloszewskiM S Losowsky
Nov 1, 1972·Klinische Wochenschrift·H RascheV Hiemeyer
Dec 8, 1972·Annals of the New York Academy of Sciences·F Duckert
Dec 8, 1972·Annals of the New York Academy of Sciences·E Ikkala
Dec 8, 1972·Annals of the New York Academy of Sciences·K LakiJ Farrell
Mar 1, 1972·Klinische Wochenschrift·W Rath, J Ströder
May 10, 1974·Deutsche medizinische Wochenschrift·F W GierhakeH G Schwick
Dec 8, 1972·Annals of the New York Academy of Sciences·T H Kiesselbach, R H Wagner
Dec 8, 1972·Annals of the New York Academy of Sciences·S T Yancey, K Laki
Feb 1, 1974·British Journal of Haematology·R D RosenbergL Lóránd
Dec 1, 1966·The American Journal of Physiology·T H Kiesselbach, R H Wagner
Jun 1, 1969·The Journal of Clinical Investigation·L LórándH L Nossel
Mar 31, 1972·Deutsche medizinische Wochenschrift·H Trobisch, R Egbring
Jul 1, 1971·The Journal of Clinical Investigation·M L SchwartzP A McKee
Oct 1, 1971·Annals of Human Genetics·J McDonaghF Duckert
Nov 23, 1971·Biochemistry·R Chen, R F Doolittle
Jul 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·P A McKeeR L Hill
Apr 23, 1971·Deutsche medizinische Wochenschrift·H G LaschW Sandritter
Jun 12, 1967·Virchows Archiv Für Pathologische Anatomie Und Physiologie Und Für Klinische Medizin·U Bleyl
Nov 1, 1969·American Journal of Clinical Pathology·E E Mandel, W M Gerhold
Jul 10, 1970·Deutsche medizinische Wochenschrift·F W GierhakeH G Schwick
Dec 1, 1970·British Journal of Haematology·K Miloszewski, M S Losowsky
Sep 1, 1971·British Journal of Haematology·R P. McDonaghF Duckert
Apr 1, 1971·British Journal of Haematology·M S Losowsky, W D Walls
May 1, 1969·The Journal of Clinical Investigation·J McDonaghR H Wagner
Oct 8, 1969·Biochemical and Biophysical Research Communications·L LórándR A Domanik
Sep 22, 1966·Biochemical and Biophysical Research Communications·S Matacić, A G Loewy
Feb 1, 1968·The Journal of Clinical Investigation·L LórándJ Bruner-Lorand
Apr 1, 1964·Archives of Biochemistry and Biophysics·L Lóránd, K KONISHI
May 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·L Lóránd, R C DICKENMAN
Sep 10, 1948·Science·K Laki, L Lóránd
Mar 9, 1964·Biochemical and Biophysical Research Communications·A G LoewyJ Eisele

Citations

Jan 1, 1989·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·T HerterD Windmann
Jan 1, 1988·Neurosurgical Review·T Herter

Related Concepts

Blood Coagulation Disorders
SDS-PAGE
Factor XIII A-Chain
Factor Xiii Deficiency
Antithrombin I
Hemorrhagic Disorders
Pregnancy Complications, Hematologic

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