Blood coagulation in the hepatic sinusoids as a contributing factor in liver injury following orthotopic liver transplantation in the rat

Transplantation
M AraiK Fujiwara

Abstract

Blood coagulation equilibrium in the hepatic sinusoids may be deranged after orthotopic liver transplantation, since tissue factor activity increases in Kupffer cells and thrombomodulin expression disappears in sinusoidal endothelial cells in orthotopically transplanted rat liver. The presence of sinusoidal blood coagulopathy and its contribution to the development of early graft failure following orthotopic liver transplantation were investigated in rats. Orthotopic liver transplantation was performed using livers preserved in cold UW solution, according to the method of Kamada, in rats. Abnormalities in the hepatic sinusoids were evaluated electron-microscopically. Anticoagulation therapy was done using antithrombin III concentrate infused immediately and 12 hr after operation. Fibrin deposition and endothelial cell destruction in the hepatic sinusoids were observed in transplanted rats 5 hr after operation. In these rats, plasma antithrombin III activity was decreased to less than 40%o of normal levels, and massive hepatic necrosis developed with increased plasma thrombin-antithrombin III complex concentration 24 hr after operation. Anticoagulation therapy significantly attenuated the extent of hepatic necrosis, with normali...Continue Reading

References

Jan 11, 1991·American Journal of Surgery·A N LangnasB W Shaw
May 1, 1967·British Journal of Haematology·D Kay, B J Cuddigan
Dec 7, 1973·Nature·P S DamusR D Rosenberg
Jan 1, 1974·Annual Review of Medicine·M VerstraeteD Collen

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Citations

Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M AraiK Fujiwara
Sep 28, 2005·Digestive Diseases and Sciences·Jota WatanabeNobuaki Kobayashi
Jul 5, 2003·The Journal of Surgical Research·Hitoshi KimuraKoichi Hirata
May 30, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Steven B YeeRobert A Roth
Jul 12, 2002·Journal of Gastroenterology·Kenji Fujiwara, Satoshi Mochida
Feb 13, 2007·The Journal of Surgical Research·Ralf BahdeHans-Ullrich Spiegel
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Atsushi KudoMakoto Suematsu
Mar 31, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Xavier StéphenneEtienne M Sokal
Sep 10, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jaap J KloekThomas M van Gulik
Oct 3, 2006·Acta Cirúrgica Brasileira·Fernando Silva RamalhoCarmen Peralta
Jan 9, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Katsutaka WatanabeMasato Nagino

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