Blood cocaine and metabolite pharmacokinetics after cardiac arrest in a body-packer case

Human & Experimental Toxicology
Nicolas de ProstAntoine Rabbat

Abstract

Cocaine body packing, the internal concealment of cocaine for transportation between countries, may expose to life-threatening intoxications. No data is currently available on the pharmacokinetics of cocaine and its metabolites when a packet rupture occurs in a body packer. We report the first pharmacokinetic data associated with a severe cocaine intoxication in a body packer, resulting in cardiac arrest. Massive concentrations of cocaine (observed maximal concentration: 1.66 mg/L, 1 hour after the cardiac arrest) were measured in plasma up to about 15 hours, suggesting a prolonged absorption due to a slow-release in the gastrointestinal tract despite surgical extraction of the packets. Apparent cocaine elimination half-life was 7.6 hours. A prolonged apparent cocaine elimination half-life has been observed. Further pharmacokinetic studies are needed to understand better the pathophysiology of acute cocaine intoxication in body packers.

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Citations

Aug 22, 2015·Journal of Forensic Sciences·Lisa B E ShieldsJohn C Hunsaker
Oct 25, 2011·Journal of Forensic and Legal Medicine·Philippe HantsonPierre Wallemacq
Apr 13, 2011·Drug and Alcohol Dependence·Gregory T CollinsJames H Woods
Oct 12, 2018·The American Journal of Forensic Medicine and Pathology·Simone CappellettiCostantino Ciallella

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