Blood compatibility of surfaces with superlow protein adsorption

Biomaterials
Zheng ZhangShaoyi Jiang

Abstract

In this work, five self-assembled monolayers (SAMs) and three polymeric brushes with very low fibrinogen adsorption were prepared. The five SAMs are oligo(ethylene glycol) (OEG), phosphorylcholine (PC), oligo(phosphorylcholine) (OPC), and two mixed positively and negatively charged SAMs of SO(3)(-)/N(+)(CH(3))(3) (SA/TMA) and COO(-)/N(+)(CH(3))(3) (CA/TMA). Three polymer brushes were prepared on gold surfaces via surface-initiated atom transfer radical polymerization (ATRP) using three monomers, sulfobetaine methacrylate (SBMA), carboxybetaine methacrylate (CBMA), and oligo(ethylene glycol) methyl ether methacrylate (OEGMA). Surface plasmon resonance (SPR) measurements show that although all of these surfaces are "nonfouling" to fibrinogen adsorption from buffer solution, their protein adsorption from undiluted human blood plasma varies widely. Polymer brushes exhibit much lower protein adsorption from plasma than any of the five SAMs tested. However, platelet adhesion measurements on plasma-preadsorbed surfaces show that all of these surfaces have very low platelet adhesion. Clotting time measurements using recalcified platelet poor plasma (PPP) incubation with the eight types of surfaces show that they do not shorten clotting...Continue Reading

References

Dec 1, 1992·Journal of Biomedical Materials Research·K IshiharaN Nakabayashi
Nov 1, 1993·Journal of Biomedical Materials Research·G R Llanos, M V Sefton
Sep 2, 1998·Journal of Biomaterials Science. Polymer Edition·H Nygren, M Broberg
Jul 9, 1999·Journal of Biomedical Materials Research·W B TsaiT A Horbett
Mar 27, 2001·Journal of Biomaterials Science. Polymer Edition·P OlssonJ Riesenfeld
May 4, 2001·Journal of Biomaterials Science. Polymer Edition·J M GrunkemeierT A Horbett
Aug 6, 2002·Journal of Biomaterials Science. Polymer Edition·Mingchao ShenThomas A Horbett
Apr 19, 2005·Journal of Biomedical Materials Research. Part a·Donna M HyltonRobert A Latour
Dec 1, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Hiromi KitanoYoshiyuki Yokoyama
Mar 8, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Shengfu ChenShaoyi Jiang
Apr 6, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Hongwei MaAshutosh Chilkoti
May 26, 2006·Applied Optics·Radan Slavík, Jirí Homola
Jun 15, 2006·The Journal of Physical Chemistry. B·Zheng ZhangShaoyi Jiang
Sep 6, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Shengfu ChenShaoyi Jiang
Nov 17, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Zheng ZhangShaoyi Jiang
Nov 17, 2006·Journal of Biomedical Materials Research. Part a·Lan CaoThomas A Horbett
Apr 9, 2008·The Journal of Physical Chemistry. B·Zheng ZhangShaoyi Jiang

❮ Previous
Next ❯

Citations

Feb 13, 2010·Analytical Chemistry·Marcio G von MuhlenScott R Manalis
Mar 17, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Chao ZhaoJie Zheng
Apr 12, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Xiangsheng LiuJian Ji
May 14, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Ching-Hsiung Shen, Jui-Che Lin
Nov 24, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·K H Aaron LauPhillip B Messersmith
Oct 30, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·King Hang Aaron LauPhillip B Messersmith
Jun 12, 2013·Physical Chemistry Chemical Physics : PCCP·Maxime CoutureJean-Francois Masson
Nov 1, 2011·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kagya A Amoako, Keith E Cook
Jun 16, 2010·Journal of Biomaterials Science. Polymer Edition·E M SrokowskiK A Woodhouse
May 7, 2014·Biomaterials Science·Yukichi HoriguchiYukio Nagasaki
May 29, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Benjamin R SimonaJános Vörös
Aug 3, 2014·Journal of Colloid and Interface Science·Chaoqun DongBaorui Liu
Nov 25, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Ching-Hsiung Shen, Jui-Che Lin
Jul 10, 2012·Chemical Society Reviews·Christophe BlaszykowskiMichael Thompson
Dec 3, 2011·Expert Review of Molecular Diagnostics·Rui Zheng, Brent D Cameron
Jan 23, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·J G VilhenaRuben Perez
Dec 24, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Oraphan WiarachaiVoravee P Hoven
Feb 5, 2013·Journal of Colloid and Interface Science·Zhihua FuYangjie Wu
Aug 23, 2012·Journal of Colloid and Interface Science·Min TangChangsheng Zhao
Nov 30, 2010·Biosensors & Bioelectronics·Wei YangShaoyi Jiang
Aug 14, 2010·Colloids and Surfaces. B, Biointerfaces·Yuuki Inoue, Kazuhiko Ishihara
Apr 20, 2010·Colloids and Surfaces. B, Biointerfaces·Jiehua LiQiang Fu
Jan 12, 2010·Biomaterials·Sook Hee KuChan Beum Park
Jan 5, 2010·Acta Biomaterialia·Lars FaxälvTomas L Lindahl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.