Blood concentrations of clonazepam and 7-aminoclonazepam in forensic cases in Denmark for the period 2002-2007

Forensic Science International : Synergy
Anni Steentoft, Kristian Linnet

Abstract

The benzodiazepine clonazepam is a prescription drug used to treat epilepsy and anxiety. In addition, it is frequently used to treat drug addicts and is itself a popular drug of abuse. In this study, we report the incidence and blood concentrations of clonazepam and its metabolite 7-aminoclonazepam in cases referred to the Section of Forensic Chemistry at the University of Copenhagen in 2002-2007. Using LC-MS/MS, clonazepam was detected in 297 traffic cases, 92 criminal cases (perpetrators or victims of a crime) and in 140 postmortem cases. The concentration ranges of clonazepam+7-aminoclonazepam were 0.002-0.840 mg/kg (median 0.067) for traffic cases, 0.005-0.913 (median 0.071) for criminal cases (offenders), 0.002-0.720 (median 0.030) for criminal cases (victims) and 0.002-1.676 (median 0.115) for postmortem cases. The concentrations were thus similar among the groups, although the median value was highest in the postmortem group. In most cases, other drugs were also present. For the postmortem group, the cases (n=27) with relatively high (>0.2 mg/kg) clonazepam+7-aminoclonazepam values were examined in greater detail. Other drugs were present in all cases, with clonazepam judged to be the primary cause of death in five cases...Continue Reading

References

Nov 30, 2000·Journal of Pharmaceutical and Biomedical Analysis·A El Mahjoub, C Staub
Oct 24, 2001·Forensic Science International : Synergy·H DruidJ Ahlner
Jul 1, 2006·Forensic Science International : Synergy·Jeffery Hackett, Albert A Elian

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Citations

Oct 13, 2009·International Clinical Psychopharmacology·Elisabeth FraugerJoëlle Micallef
Feb 18, 2014·Forensic Science International : Synergy·Anna Kristina JönssonHenrik Druid
Nov 26, 2009·Journal of Travel Medicine·Ender SenolMeltem Islam
May 14, 2011·Fundamental & Clinical Pharmacology·Elisabeth FraugerUNKNOWN réseau des CEIPs
Sep 30, 2016·Forensic Science International : Synergy·Louise SkovKristian Linnet
Jul 12, 2013·Toxicology and Industrial Health·Tarek Mostafa MohamedRabee M R El Husseiny
Jan 26, 2018·American Journal of Therapeutics·Habibe Koç UçarGökhan Kalkan

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