PMID: 3300583Jul 1, 1987Paper

Blood conservation with membrane oxygenators and dipyridamole

The Annals of Thoracic Surgery
K H TeohP Reilly

Abstract

Cardiopulmonary bypass induces platelet activation and dysfunction, which result in platelet deposition and depletion. Reduced platelet numbers and abnormal platelet function may contribute to postoperative bleeding. A membrane oxygenator may preserve platelets and reduce bleeding more than a bubble oxygenator, and the antiplatelet agent dipyridamole may protect platelets intraoperatively and reduce bleeding postoperatively. A prospective randomized trial was performed in 44 patients undergoing elective coronary artery bypass grafting to assess the effects of the membrane oxygenator and dipyridamole on platelet counts, platelet activation products, and postoperative bleeding. Patients who were randomized to receive a bubble oxygenator and no dipyridamole had the lowest postoperative platelet counts, the greatest blood loss, and the most blood products transfused. Platelet counts were highest and blood loss was least in patients randomized to receive a membrane oxygenator and dipyridamole (p less than .05). A bubble oxygenator with dipyridamole and a membrane oxygenator without dipyridamole resulted in intermediate postoperative platelet counts and blood loss. Arterial thromboxane B2 and platelet factor 4 concentrations were ele...Continue Reading

References

Apr 1, 1983·The Annals of Thoracic Surgery·M BoersC R Wildevuur
Feb 26, 1981·The New England Journal of Medicine·D E ChenowethJ W Kirklin

Citations

May 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J F HardyM Carrier
Feb 1, 1995·The Annals of Thoracic Surgery·R G SpeekenbrinkL Eijsman
Feb 4, 1999·The Annals of Thoracic Surgery·A Weerasinghe, K M Taylor
Oct 1, 1994·Journal of Cardiothoracic and Vascular Anesthesia·W G ReeveD C Smith
Jan 1, 1990·Thrombosis Research. Supplement·K H TeohM F Glynn
Jul 1, 1988·Current Problems in Cardiology·W J PennyV Fuster
Nov 28, 2001·The Annals of Thoracic Surgery·G J DespotisC W Hogue
Jun 1, 1988·The Annals of Thoracic Surgery·G A PattersonR J Ginsberg
May 1, 1993·The Annals of Thoracic Surgery·M KawasujiY Watanabe
Oct 9, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Assad HaneyaChristof Schmid
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·L T Goodnough, G J Despotis

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