PMID: 16514171Mar 4, 2006Paper

Blood corticosterone concentration reaches critical illness levels early during acute malnutrition in the weanling mouse

Experimental Biology and Medicine
Jennifer M MonkB D Woodward

Abstract

Acute (i.e., wasting) pediatric malnutrition consistently elevates blood glucocorticoid levels, but neither the magnitude of the rise in concentration nor its kinetics is clear. Male and female C57BL/6J mice, initially 19 days old, and CBA/J mice, initially 23 days old, consumed a complete purified diet either ad libitum (age-matched control) or in restricted daily quantities (mimicking marasmus), or they consumed a purified isocaloric low-protein diet ad libitum (mimicking incipient kwashiorkor). Serum levels of corticosterone were assessed by double antibody radioimmunoassay after 3, 6, and 14 days (C57BL/6J strain) or after 6 and 14 days in the genetically distant CBA/J strain. Age-matched control groups of both strains exhibited mean corticosterone levels of 5-30 ng/ml, whereas the acutely malnourished groups exhibited mean levels of this hormone that were elevated by more than an order of magnitude as early as 3 days after initiation of weight loss. This outcome was confirmed in a second experiment in which the serum corticosterone level of C57BL/6J weanlings was examined by competitive binding enzyme immunoassay 3 and 14 days after initiation of the dietary protocols. Therefore, deficits of protein and/or energy in weanli...Continue Reading

References

Aug 26, 1972·Lancet·M M SchonlandH M Coovadia
Nov 5, 1997·The New England Journal of Medicine·S W LambertsF H de Jong
Nov 15, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L M Hillyer, Bill Woodward

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Citations

Oct 6, 2009·The Journal of Veterinary Medical Science·Zhixiong HeZhiliang Tan
Dec 17, 2008·Clinical and Experimental Immunology·R OrtizH Medina
Oct 2, 2015·The Journal of Nutrition·Mariam AlaverdashviliPhyllis G Paterson
Nov 23, 2007·Seminars in Cell & Developmental Biology·R Michael RobertsAngela M Walker

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