Blood culture-based diagnosis of bacteraemia: state of the art

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
O OpotaGilbert Greub

Abstract

Blood culture remains the best approach to identify the incriminating microorganisms when a bloodstream infection is suspected, and to guarantee that the antimicrobial treatment is adequate. Major improvements have been made in the last years to increase the sensitivity and specificity and to reduce the time to identification of microorganisms recovered from blood cultures. Among other factors, the introduction in clinical microbiology laboratories of the matrix-assisted laser desorption ionization time-of-flight mass spectrometry technology revolutionized the identification of microorganisms whereas the introduction of nucleic-acid-based methods, such as DNA hybridization or rapid PCR-based test, significantly reduce the time to results. Together with traditional antimicrobial susceptibility testing, new rapid methods for the detection of resistance mechanisms respond to major epidemiological concerns such as methicillin-resistant Staphylococcus aureus, extended-spectrum β-lactamase or carbapenemases. This review presents and discusses the recent developments in microbial diagnosis of bloodstream infections based on blood cultures.

References

Jun 9, 1977·The New England Journal of Medicine·D G MakiH W Sarafin
Oct 1, 1966·Medical Times·E A Stead
Dec 20, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara E CosgroveYehuda Carmeli
Jul 10, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R ZaragozaJ M Nogueira
Jul 1, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F R CockerillW R Wilson
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hilmar WisplinghoffMichael B Edmond
Dec 8, 2004·Journal of Clinical Microbiology·Laura Lindholm, Hannu Sarkkinen
Nov 4, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ellen Jo BaronLucy S Tompkins
Oct 17, 2006·Clinical Microbiology Reviews·Keri K Hall, Jason A Lyman
May 11, 2007·Expert Review of Molecular Diagnostics·Graeme N Forrest
Sep 21, 2007·Journal of Clinical Microbiology·Andrew LeeMelvin P Weinstein
Jul 9, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Piseth SengDidier Raoult
Oct 2, 2009·Journal of Clinical Microbiology·Wilson I GonsalvesMeera Varman
Nov 4, 2009·Antimicrobial Agents and Chemotherapy·Ying TaurSusan K Seo
Jun 8, 2010·Surgical Infections·John C MarshallMitchell Levy
Aug 18, 2010·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hiroki IshikawaTetsuya Matsumoto
Aug 25, 2010·Antimicrobial Agents and Chemotherapy·Mical PaulLeonard Leibovici
Sep 10, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·W MoussaouiG Prévost
Oct 15, 2010·Journal of Clinical Microbiology·Richard G Patton, Timothy Schmitt
Oct 28, 2011·American Journal of Clinical Pathology·David H SpencerCarey-Ann D Burnham
Nov 19, 2011·FEMS Microbiology Reviews·Antony CroxattoGilbert Greub
Jan 12, 2012·Mycoses·Claudio FarinaUNKNOWN Medical Mycology Committee (CoSM) ‘Fungemia Diagnosis Study Group’, Italian Society of Clinical Microbiology (AMCLI)
Sep 25, 2012·Diagnostic Microbiology and Infectious Disease·Anne J BlaschkeMark A Poritz
Oct 30, 2012·The Lancet Infectious Diseases·Mitchell M LevyR Phillip Dellinger
Jan 1, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G A March-RossellóM A Bratos-Pérez
Jan 9, 2013·Annals of Clinical Microbiology and Antimicrobials·Dana M Harris, D Jane Hata
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Feb 2, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L HuangL Y Sun

❮ Previous
Next ❯

Citations

Feb 19, 2016·Virulence·Claudio Viscoli
Jan 26, 2016·Journal of Microbiological Methods·S DinarelliG Longo
Dec 25, 2015·Current Infectious Disease Reports·Joseph B CanteySarah M McCormick
Mar 31, 2016·Future Microbiology·Gilbert GreubKatia Jaton
Jun 20, 2016·Biosensors & Bioelectronics·Baris A BorsaV Cengiz Ozalp
May 25, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M-A ColombierG Socie
Aug 11, 2016·Frontiers in Microbiology·Claude Saint-RufIvan Matic
Oct 16, 2016·Environmental Research·Natalija Topić PopovićRozelindra Čož-Rakovac
Dec 23, 2016·Expert Review of Molecular Diagnostics·Li Zhang, C M Rickard
Aug 30, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M OsthoffA Egli
Jan 8, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P StuparS Kasas
Jan 28, 2017·Journal of Medical Microbiology·Johannes BrenneckeTill Bachmann
Mar 21, 2017·Current Opinion in Infectious Diseases·Garth Dixon, Georgi Christov
Jan 4, 2017·Pediatric Emergency Care·Loren G Yamamoto
Feb 7, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Itay BergerGili Kadmon
Jun 24, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F Tagini, G Greub
Jul 13, 2018·Infectious Diseases·María Guembe, Carlos Sánchez-Carrillo
Mar 2, 2018·Clinical Microbiology Reviews·Mridu SinhaStephanie I Fraley
Sep 16, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Giuseppe Vittorio De SocioAntonella Mencacci
Jan 10, 2019·Annals of Laboratory Medicine·Seong Chun KimSeong Mi Yu
Jan 15, 2019·Expert Review of Molecular Diagnostics·Grégory DubourgFlorence Fenollar
Sep 7, 2018·Angewandte Chemie·Yingdi ZhuHubert H Girault
Nov 30, 2018·Journal of Clinical Microbiology·Te-Din HuangYouri Glupczynski
Jun 1, 2018·Nature Reviews. Disease Primers·Andie S LeeStephan Harbarth
Oct 23, 2019·The Journal of Applied Laboratory Medicine·Linoj Samuel
Mar 7, 2020·Journal of Medical Microbiology·Martin P McHugh Scottish Microbiology And Virology Network Smvn Molecular Diagnostics Evaluation Group
Apr 2, 2020·International Journal of Molecular Sciences·Denis V VoroninDaniil N Bratashov
Mar 13, 2020·Klinicheskaia laboratornaia diagnostika·N M KargaltsevaO Y Borisova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.