Blood-direct InvaderPlus® as a new method for genetic testing

Personalized Medicine
Akira HirasawaDaisuke Aoki

Abstract

This study compared the efficiency of Blood-direct InvaderPlus® with existing methods for detecting genetic polymorphisms by using clinical samples, and to determine whether this new method can be used for future clinical studies. We developed a new method, called Blood-direct InvaderPlus, for detecting genetic polymorphisms. Whole-blood samples were subjected to genetic analysis with the new method and also the conventional method. The results obtained with the new method were consistent with those of direct sequencing. Blood-direct InvaderPlus was able to detect gene polymorphisms of UGT1A1*6, *27, *28, *60, VKORC1 -1639G>A, VKORC1 1173T>C and CYP2C9 *2 and *3 much faster than the conventional methods. Blood-direct InvaderPlus allowed accurate, simple and rapid detection of genetic polymorphisms.

References

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Methods Mentioned

BETA
genotyping
PCR
FRET

Software Mentioned

InvaderPlus
Ampdirect

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