PMID: 6979270May 1, 1982Paper

Blood disoprofol levels in anesthetised patients. Correlation of concentrations after single or repeated doses with hypnotic activity

Anaesthesia
H K AdamE J Douglas

Abstract

The blood concentrations of disoprofol (Diprivan) after single intravenous doses of 1, 2 or 3 mg/kg have been examined in a subpopulation from previously reported clinical studies. The linear relationship between sleep time and dose could be explained by the linearity of the pharmacokinetics at these doses. After a single injection the awakening concentration was independent of dose, with a mean value of 1.04 micrograms/ml. No acute tolerance occurred with disoprofol. On repeated 1 mg/kg bolus injections the sleeping time rose initially but stabilised after four doses. The waking concentration was independent of the number of doses administered. The clinical findings fitted an agent with a very rapid distribution phase and a short elimination half-life.

References

Sep 1, 1977·Clinical Pharmacokinetics·M M Ghoneim, K Korttila
Dec 1, 1979·British Journal of Anaesthesia·J IdvallP Stenberg
Aug 1, 1980·British Journal of Anaesthesia·J B Glen
Aug 1, 1980·British Journal of Anaesthesia·H K AdamP A Hoyle
Aug 1, 1980·British Journal of Anaesthesia·K M RogersA A Spence
Mar 1, 1981·British Journal of Anaesthesia·E MajorW Aveling
May 1, 1980·Anaesthesia·J W DundeeP J Howard
Sep 1, 1980·British Journal of Anaesthesia·J H ChristensenJ A Jansen
Aug 1, 1956·British Journal of Anaesthesia·R D DRIPPSH L PRICE

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Citations

Oct 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P J SimonsR J Ruane
Apr 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P J SimonsM Rowland
Jan 1, 1987·Anaesthesia·N Mackenzie, I S Grant
Jan 1, 1990·Psychopharmacology·D B Campbell
Aug 1, 1988·British Journal of Clinical Pharmacology·G A CampbellD P Crankshaw
Sep 28, 2007·Therapeutic Drug Monitoring·Yitzchak RamonYedidia Bentur
Jul 1, 1983·Anaesthesia·M Morgan
Dec 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R I Hall
Mar 28, 2002·Anesthesia and Analgesia·Kai-Michael Scheufler, Josef Zentner
Jan 1, 1991·Annals of the New York Academy of Sciences·G Levy

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