Blood donor testing for hepatitis B virus in the United States: is there a case for continuation of hepatitis B surface antigen detection?

Transfusion
Roger Y DoddSusan L Stramer

Abstract

In the United States, blood donor testing for hepatitis B surface antigen (HBsAg) was initiated in the early 1970s. More recently, testing for antibody to hepatitis B core antigen (anti-HBc) and hepatitis B virus (HBV) DNA have been added. The incidence of hepatitis B has been declining. This study reviews the current status of testing and questions the need for continuation of HBsAg testing. From July 2011 to June 2015, a total of 22.4 million donations were serologically tested for HBsAg and anti-HBc and for HBV-DNA by nucleic acid testing (NAT). All reactive results were evaluated and a subset of donations that were either potential NAT yield (seronegative) or serologically positive but nonreactive by HBV NAT in minipools (MPs) of 16 were further evaluated by individual donation (ID)-NAT. Samples with detectable HBV DNA were defined as actively infected and considered potentially infectious. Routine testing plus supplemental ID-NAT identified 2035 samples representing active infection including 1965 with anti-HBc, 1602 with HBsAg, and 1453 with HBV DNA by MP-NAT, for respective rates per hundred-thousand donations of 9.10, 8.78, 7.16, and 6.50, continuing the downward trend previously observed. There were 29 HBV DNA-yield sa...Continue Reading

References

Apr 5, 2013·Transfusion·Susan L StramerSteven H Kleinman
Dec 14, 2016·The New England Journal of Medicine·Erin D MoritzSusan L Stramer
Oct 12, 2017·The New England Journal of Medicine·Harvey G KleinJay S Epstein

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Citations

Mar 1, 2019·Vox Sanguinis·Clive R SeedErhard Seifried
Apr 12, 2019·Vox Sanguinis·Clive R SeedMichael Schmidt
Feb 6, 2020·Vox Sanguinis·Heinrich ScheiblauerMichael Chudy
Dec 6, 2020·Vox Sanguinis·Tapiwa Blessing Matanhire, Shi-Woei Lin
Mar 10, 2021·Transfusion·Anna S NishiyaAlfredo Mendrone-Jr

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