Blood eosinophil count as a predictor of hospital length of stay in COPD exacerbations.

Respirology : Official Journal of the Asian Pacific Society of Respirology
Fanny W S KoDavid S C Hui

Abstract

Airway inflammation accompanying exacerbations varies among individuals with some having neutrophilic, while others showing eosinophilic inflammation. This study assessed the cut-off values of blood eosinophil count for identifying subjects with longer hospital length of stay (LOS) with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Patients were recruited at presentation to the hospital with an AECOPD. Complete blood picture with differential count was taken on admission. Patients were treated with a standard course of systemic corticosteroid and antibiotic and evaluated at 8 weeks post-exacerbation for lung function measurement and 6-min walk. They were followed up in 1 year for any readmissions or mortality. Cut-off values of eosinophils for assessment of longer LOS were calculated using receiver operating characteristic (ROC) curve analysis. A total of 346 patients with admission eosinophil count were included in the analysis (333 (96.2%) were males; mean ± SD age: 74.9 ± 7.8 years; mean forced expiratory volume in 1 s (FEV1 ): 43.4 ± 16.3% predicted). The median (interquartile range (IQR)) of the absolute peripheral eosinophil count, percent eosinophil count and LOS were 0.11 (0.25) × 109 /L, 1 (3) ...Continue Reading

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Citations

Aug 31, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Angela Moran, Ian D Pavord
Dec 21, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Fanny W S Ko, David S C Hui
Mar 5, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Fanny W S KoDavid S C Hui
Mar 5, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Shiping ZhuWanru Cai
Mar 17, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Konstantinos KostikasStelios Loukides
Jul 15, 2021·Seminars in Respiratory and Critical Care Medicine·Holly R Keir, James D Chalmers
Oct 13, 2021·The Korean Journal of Internal Medicine·Andrew LiHui-Fang Lim
Oct 10, 2021·The Clinical Respiratory Journal·Nilüfer Aylin Acet-ÖztürkEsra Uzaslan

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