Blood exchange and transfusion therapy for acute cholestasis in protoporphyria

Digestive Diseases and Sciences
H J van WijkJ H Wilson


Acute cholestasis is a rare complication of EPP with a high mortality rate despite extensive treatment with corticosteroids, cholestyramine, and antioxidants. A single survivor, reported in the literature, was treated with blood exchange transfusions. We treated two EPP patients with blood exchange and additional blood transfusions which resulted in full clinical and biochemical recovery from the cholestasis and accompanying hepatitis. Recurrences of the cholestasis and hepatitis could repeatedly be corrected by additional blood transfusions.


Mar 1, 1978·The British Journal of Dermatology·D J Cripps, S S Goldfarb
Oct 2, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·J H WilsonL H van Gastel-Quist
Jun 1, 1975·The American Journal of Medicine·J R Bloomer Bloomer
Sep 16, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·A F De GoeijL N Went
Sep 12, 1975·European Journal of Clinical Investigation·A F de GoeijJ van Steveninck
Jul 1, 1986·Annals of Internal Medicine·V R GordeukD R Bickers
Dec 1, 1973·Gut·R P ThompsonC H Gray
Dec 1, 1971·Clinical Toxicology·C L Witzleben, B E Buck
Jan 1, 1971·The British Journal of Dermatology·E M DonaldsonT Hargreaves
Mar 1, 1968·Journal of Clinical Pathology·H D BarnesJ H Millar
Sep 1, 1982·Archives of Dermatology·I RomsloG Høvding
Jan 1, 1981·Virchows Archiv. A, Pathological Anatomy and Histology·Y NakanumaG Ohta

❮ Previous
Next ❯


Jul 1, 1996·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J R BloomerR L Carithers
Feb 9, 2011·Journal of Inherited Metabolic Disease·Joanna K DowmanUNKNOWN UK Liver Selection and Allocation Working Party
May 26, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·N AsadaY Horie
Apr 29, 1998·Clinics in Dermatology·M B Poh-Fitzpatrick
Feb 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·P Williams-AryaN W Wilson
Jun 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A FontanellasH de Verneuil
Nov 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·C PotterJ Bloomer
Nov 1, 1992·The British Journal of Dermatology·D J ToddD Burrows
Feb 1, 1994·The British Journal of Dermatology·R P Sarkany, P G Norris
Dec 1, 1994·The British Journal of Dermatology·D J Todd
May 1, 1991·Clinical and Experimental Dermatology·S A ShehadeR J Prescott
Feb 1, 1996·Pediatric Clinics of North America·S J Schwarzenberg, H L Sharp
Jun 21, 2016·Journal of Clinical Apheresis
Feb 1, 1994·Annals of Medicine·R KauppinenP Mustajoki
Jan 28, 2017·Integrated Environmental Assessment and Management·Dagmar DaehneMichael Feibicke
Jun 30, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Karin E R GooijertHenkjan J Verkade
Jan 29, 2021·Expert Review of Clinical Pharmacology·Debby WensinkJanneke G Langendonk
Jan 22, 2005·Transfusion·Quentin G EichbaumZbigniew M Szczepiorkowski
Jun 1, 1997·Journal of Inherited Metabolic Disease·T M Cox

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

© 2021 Meta ULC. All rights reserved