Blood factory: which stem cells?

BMC Hematology
Maria Teresa Esposito

Abstract

Blood transfusions are often essential for treatment of severe anaemia and pregnancy complications. The unavailability of blood is a medical concern, especially in developing countries. New sources of red blood cells (RBC) are under investigation. Several studies have attempted to produce functional RBC from CD34+ haematopoietic stem cells (HSC) isolated from peripheral blood and umbilical cord blood, from embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC). A recent article published in Nature Communications describes a novel model for generating RBC from a stable erythroid cell line obtained from bone marrow CD34+ haematopoietic stem cells (HSC). The cells generated by this method are phenotypically and functionally adult RBC, that resemble very well the donor RBC. In vivo experiments confirmed no difference in the survival of these RBC and donor RBC. The study therefore highlights that this immortalized line is a promising new source of adult RBC.

References

May 1, 2002·Nature Biotechnology·Thi My Anh Neildez-NguyenLuc Douay
Dec 28, 2004·Nature Biotechnology·Marie-Catherine GiarratanaLuc Douay
Jan 18, 2006·Stem Cells·Kristian M BowlesRoger A Pedersen
May 9, 2007·Nature Methods·Shi-Jiang LuRobert Lanza
Nov 22, 2007·Science·Junying YuJames A Thomson
Aug 30, 2008·Regenerative Medicine·Shi-Jiang LuRobert Lanza
Sep 3, 2011·Blood·Marie-Catherine GiarratanaLuc Douay
Jul 26, 2014·Emergency Medicine Clinics of North America·Jessica L Osterman, Sanjay Arora
Jul 9, 2016·Stem Cells Translational Medicine·Kiran BattaValerie Kouskoff
Sep 2, 2016·Haematologica·Maria Teresa Esposito
Jun 16, 2017·Stem Cells Translational Medicine·Yu ZhangYongping Jiang

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Citations

Sep 12, 2018·Physiological Research·M Trávníčková, L Bačáková
Nov 18, 2020·Stem Cell Research & Therapy·Mohsen EbrahimiMaryam Farzaneh
Feb 29, 2020·Regenerative Therapy·Edward H NtegeYusuke Shimizu
Nov 2, 2021·Stem Cells Translational Medicine·Xiaoyan XieXuetao Pei

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Methods Mentioned

BETA
leukapheresis

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