Blood feeding induces hemocyte proliferation and activation in the African malaria mosquito, Anopheles gambiae Giles

The Journal of Experimental Biology
William B Bryant, Kristin Michel

Abstract

Malaria is a global public health problem, especially in sub-Saharan Africa, where the mosquito Anopheles gambiae Giles serves as the major vector for the protozoan Plasmodium falciparum Welch. One determinant of malaria vector competence is the mosquito's immune system. Hemocytes are a critical component as they produce soluble immune factors that either support or prevent malaria parasite development. However, despite their importance in vector competence, understanding of their basic biology is just developing. Applying novel technologies to the study of mosquito hemocytes, we investigated the effect of blood meal on hemocyte population dynamics, DNA replication and cell cycle progression. In contrast to prevailing published work, the data presented here demonstrate that hemocytes in adult mosquitoes continue to undergo low basal levels of replication. In addition, blood ingestion caused significant changes in hemocytes within 24 h. Hemocytes displayed an increase in cell number, size, granularity and Ras-MAPK signaling as well as altered cell surface moieties. As these changes are well-known markers of immune cell activation in mammals and Drosophila melanogaster Meigen, we further investigated whether a blood meal changes ...Continue Reading

References

Aug 23, 1990·Nature·J DownwardD A Cantrell
Jan 1, 1983·Developmental and Comparative Immunology·D W Hall
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·S LuckhartR Rosenberg
Mar 1, 2000·British Medical Bulletin·G Bellingan
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·A DanielliF C Kafatos
Feb 24, 2001·Proceedings. Biological Sciences·A R KraaijeveldH C Godfray
Apr 3, 2003·Immunological Reviews·Doreen Ann Cantrell
Oct 11, 2003·Development Genes and Evolution·James B NardiMichael R Kanost
Sep 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Carl-Johan ZettervallDan Hultmark
Sep 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew D CookJohn A Hamilton
Sep 29, 2005·The Journal of Biological Chemistry·Jennifer VolzHans-Michael Müller
Aug 23, 2006·Cellular Microbiology·Jennifer VolzMike A Osta
Nov 14, 2006·Insect Biochemistry and Molecular Biology·J C CastilloM R Strand
Jun 1, 2007·The Journal of Biological Chemistry·Anna K D SchnitgerMike A Osta
Nov 4, 2009·Genes & Development·Hyun O LeeRobert J Duronio
Nov 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sofia B PintoKristin Michel
Sep 11, 2010·Science·Janneth RodriguesCarolina Barillas-Mury
Oct 19, 2010·Cellular and Molecular Life Sciences : CMLS·Chunju AnKristin Michel
Jan 1, 2010·Advances in Experimental Medicine and Biology·Julián F Hillyer
Jan 28, 2012·Science·Giselle de Almeida OliveiraCarolina Barillas-Mury
Mar 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian L WeissSerap Aksoy
Apr 28, 2012·Current Opinion in Microbiology·Christian Mitri, Kenneth D Vernick
Dec 5, 2012·PLoS Pathogens·Jonas G King, Julián F Hillyer
Apr 27, 2013·Nature·Thomas A WynnJeffrey W Pollard
Jul 28, 2013·Journal of Innate Immunity·Jose Luis RamirezCarolina Barillas-Mury

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Citations

Jun 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ryan C SmithMarcelo Jacobs-Lorena
Jan 23, 2016·Journal of Medical Entomology·D E SolimanL C Bartholomay
Dec 24, 2015·Developmental and Comparative Immunology·Julián F Hillyer
Oct 31, 2015·Developmental and Comparative Immunology·William B Bryant, Kristin Michel
Aug 4, 2015·Environmental Science and Pollution Research International·Sapna MishraAnushree Malik
Oct 2, 2015·Malaria Journal·Romain PigeaultAna Rivero
Oct 14, 2014·Current Opinion in Insect Science·Julián F Hillyer, Michael R Strand
Sep 19, 2016·Trends in Parasitology·Ryan C Smith, Carolina Barillas-Mury
Apr 21, 2017·PloS One·Salvador Hernández-MartínezFernando G Noriega
Jul 3, 2019·Proceedings of the National Academy of Sciences of the United States of America·Michael T Siva-JothyEwan Harney
Jan 13, 2018·Annual Review of Entomology·Lyric C Bartholomay, Kristin Michel
Jul 25, 2018·Proceedings of the National Academy of Sciences of the United States of America·Maiara S SeveroElena A Levashina
Jun 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Hyeogsun Kwon, Ryan C Smith
Apr 28, 2018·Parasitology Research·Jéssica Fiorotti de PauloVânia Rita Elias Pinheiro Bittencourt
Jun 14, 2019·Frontiers in Physiology·Jéssica FiorottiVânia Rita Elias Pinheiro Bittencourt
Aug 29, 2020·Science·Gianmarco RaddiOliver Billker
Jun 12, 2020·Journal of Invertebrate Pathology·Rashaun PottsJose E Pietri
Aug 5, 2019·Developmental and Comparative Immunology·Jonas G King
Feb 28, 2020·Insect Biochemistry and Molecular Biology·Emilie PondevilleCatherine Bourgouin
Feb 10, 2020·Trends in Immunology·Sarah Hélène Merkling, Louis Lambrechts

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