Blood flow distribution in the normal human preterm brain

Pediatric Research
K Børch, G Greisen

Abstract

Disturbances in cerebral blood flow (CBF) are a major factor in the etiology and pathogenesis of cerebral damage in the neonate. As most animals are more mature at birth than man, extrapolation from animal studies to the human is questionable. Therefore, we have measured regional CBF (rCBF) in preterm infants. rCBF flow was measured in 12 normotensive and normoxic preterm infants [mean birth weight 915 g (range 550 to 2680 g), mean gestational age 27.7 wk (25 to 32 wk)]. All infants had a normal cerebral ultrasound examination. rCBF was measured using a mobile brain dedicated fast-rotating four-head multidetector system specially designed for neonatal studies. The tracer was 99mTc-labeled D,L-hexamethylpropylenamine oxime in a dose of 4 Mbq/kg. rCBF of the subcortical white matter was 0.53 (0.48-0.58) of the global CBF. After correction for scattered radiation, the estimate of rCBF to the white matter was reduced to 0.39 (0.36-0.42). The flow to the basal ganglia was 2.33 (2.08-2.59) times the global CBF. After correction for partial volume effect, the cortical flow was higher than the flow to the basal ganglia and highest in the frontotemporal cortex (motor cortex). The flow to the cerebellum was of the same magnitude as the f...Continue Reading

References

Jun 1, 1979·Journal of Computer Assisted Tomography·E J HoffmanM E Phelps
Jan 1, 1979·The Journal of Pediatrics·H C LouB Friis-Hansen
Oct 1, 1977·Acta Neurologica Scandinavica·H C LouB Friis-Hansen
Mar 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D A RottenbergM L Sergi
Mar 1, 1990·Clinical Nuclear Medicine·D S FockeleU Y Ryo
Jan 1, 1986·Acta paediatrica Scandinavica·G Greisen
Jun 1, 1989·Journal of Applied Physiology·J M GoplerudM Delivoria-Papadopoulos
Jan 1, 1988·The Journal of Pediatrics·D YounkinW Obrist
Oct 1, 1987·Annals of Neurology·H T ChuganiJ C Mazziotta
May 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·G GreisenB Friis-Hansen
Jul 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·H M ShapiroM Reivich
Mar 1, 1982·Annals of Neurology·M Cavazzuti, T E Duffy
Aug 30, 1995·Early Human Development·P B ToftO Henriksen
Nov 1, 1995·European Journal of Pediatrics·O BaenzigerH U Bucher
Apr 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K Børch, G Greisen

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Citations

Oct 23, 2001·Archives of Disease in Childhood. Fetal and Neonatal Edition·B R PalG M Durbin
Jun 23, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Topun Austin
Feb 26, 2008·Archives of Disease in Childhood. Fetal and Neonatal Edition·O Khwaja, J J Volpe
Sep 12, 2009·Journal of Child Neurology·Adré J du Plessis
Feb 14, 2012·Cerebral Cortex·Pei-Yi LinMaria Angela Franceschini
Aug 15, 2013·Neuroradiology·Anand S PanditSerena J Counsell
Mar 22, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nadine BrewFlora Y Wong
May 3, 2007·European Radiology·Jeremy C Hebden, Topun Austin
Dec 2, 2008·Paediatric Anaesthesia·Elöd Z SzabóBruno Bissonnette
May 12, 2010·Acta Paediatrica·Klaus BørchGorm Greisen
Apr 8, 2016·Neonatal Network : NN·Dawn Gano
Jan 16, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Julie B AndersenIan Law
Mar 6, 2004·Annals of the New York Academy of Sciences·Bradley S Peterson
Jan 19, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·William C Hanigan, Donna Bogner
Feb 3, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Margie Castillo-MelendezSuzanne L Miller
Jun 11, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Julie B AndersenIan Law
May 21, 2016·Frontiers in Neurology·Prakasham RumajogeeMichael G Fehlings
Apr 25, 2009·Pediatric Research·Pavithra LogitharajahFrances M Cowan
Jun 30, 2006·Mental Retardation and Developmental Disabilities Research Reviews·Stephen A Back
Jul 9, 2013·Neuroradiology·Charles RaybaudMutaz Al Nassar
Mar 1, 2011·Expert Opinion on Medical Diagnostics·Topun Austin, Helen O'Reilly
Feb 8, 2005·Seminars in Perinatology·Stephen A Back, Scott A Rivkees
Jun 4, 1999·The Journal of Pediatrics·A LevitonM Pagano
Aug 2, 2021·Pediatric Radiology·Memduha GumusJudy H Squires

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