Blood Flow during Handgrip Exercise in COPD: Effect of Vitamin C

Medicine and Science in Sports and Exercise
Sara E HartmannMarc J Poulin

Abstract

Chronic obstructive pulmonary disease (COPD) is associated with vascular dysfunction, possibly related to increased oxidative stress. Exercise hyperemia may similarly be impaired, which could have implications for exercise limitations in COPD. We tested if brachial blood flow (BBF) was reduced during handgrip exercise in COPD and if this response would be improved after vitamin C infusion. Doppler ultrasound was used to measure brachial blood flow and vascular conductance (BBF and BVC, respectively) during mild, rhythmic handgrip exercise (EX) under conditions of sham-saline and vitamin C. Measures of flow-mediated dilation (FMD) and nitroglycerine-mediated dilation were used to assess endothelial-dependent and independent dilation, respectively. Biomarkers of antioxidants (vitamin C, superoxide dismutase [SOD], catalase), oxidative stress (malondialdehyde [MDA], advanced oxidation protein products [AOPP]), and nitric oxide metabolism (NOx) were measured in blood plasma. Ten COPD patients with moderate COPD and 10 healthy age-matched controls participated. COPD patients had similar increases in BBF and BVC during EX, compared with controls. Vitamin C was not found to have an effect on blood flow parameters during exercise (P > ...Continue Reading

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Mar 4, 2017·Journal of Applied Physiology·Daniel M HiraiJ Alberto Neder
Jun 9, 2017·Internal and Emergency Medicine·Pasquale AmbrosinoMatteo Nicola Dario Di Minno
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Apr 21, 2021·Expert Review of Respiratory Medicine·Marieta P TheodorakopoulouAfroditi K Boutou

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