Blood flow in dermal allergen-induced immediate and late-phase reactions

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
A HammarlundU Pipkorn

Abstract

Changes in local skin blood flow after prick-tests with histamine and allergen challenge were evaluated using laser doppler flowmetry. Two series of measurements were performed; each included 11 subjects with seasonal allergic rhinitis. In the first series vascular reactions were registered intermittently for a period of 6 hr. This was then repeated with additional registrations after 14 and 24 hr. Registrations were made in the skin close to where the test substances were applied which was in the area of the initial weal reaction. Pre-loaded skin-prick test needles were used for the histamine and allergen tests. Controls using 'blank' needles were also set on the same occasion. The control induced a transient increase in blood flow which had disappeared after 1 hr. After histamine challenge, the initial rapid increase in blood flow was followed by a slow return to baseline within 1 hr, and no further changes were noticed during the registration period. A different blood flow response was seen after the application of allergen. After an initial increase, the blood flow remained at this higher level for more than 6 hr. Thereafter a slow decrease towards baseline was seen within 24 hr. The pronounced difference between the histam...Continue Reading

References

Aug 1, 1976·The Journal of Clinical Investigation·G O SolleyA L Schroeter
Jul 11, 1985·The New England Journal of Medicine·R M NaclerioL M Lichtenstein
Aug 1, 1988·The Journal of Allergy and Clinical Immunology·P OlssonU Pipkorn
Sep 1, 1984·The Journal of Investigative Dermatology·H Bisgaard, J K Kristensen
Jun 15, 1981·Applied Optics·R Bonner, R Nossal

❮ Previous
Next ❯

Citations

Jul 1, 1995·Clinics in Dermatology·H C Eun
Apr 2, 2011·Medical Physics·Eugeniusz RokitaGrzegorz Tatoń
May 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A HammarlundU Pipkorn
Mar 16, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P Devillier, J Bousquet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.